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ML382

Name: ML382
Brand: TargetMol
SKU: T8538
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8538Cas No. 1646499-97-9

ML382 is a potent and selective MrgX1 positive allosteric modulator (EC50 : 190 nM).

ML382

🥰Excellent

Purity: 99.79%

Catalog No. T8538Cas No. 1646499-97-9

ML382 is a potent and selective MrgX1 positive allosteric modulator (EC50 : 190 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$41	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$131	In Stock	In Stock
50 mg	$238	In Stock	In Stock
100 mg	$353	In Stock	In Stock
200 mg	$493	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.79%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ML382 is a potent and selective MrgX1 positive allosteric modulator (EC50 : 190 nM).
Targets&IC50	MrgX1:190 nM(EC50)
In vivo	ML382 enhances the ability of BAM8-22 to inhibit high-voltage-activated Ca2+ channels and attenuate spinal nociceptive transmission, both BAM8-22 and ML382 effectively attenuated evoked, persistent, and spontaneous pain without causing obvious side effects.?Notably, ML382 by itself attenuated both evoked pain hypersensitivity and spontaneous pain in MrgprX1 mice after nerve injury without acquiring coadministration of an exogenous agonist[2]

Chemical Properties

Molecular Weight	360.43
Formula	C₁₈H₂₀N₂O₄S
Cas No.	1646499-97-9
Smiles	CCOc1ccccc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1
Relative Density.	1.34 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32.5 mg/mL (90.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7745 mL	13.8723 mL	27.7446 mL	138.7232 mL
5 mM	0.5549 mL	2.7745 mL	5.5489 mL	27.7446 mL
10 mM	0.2774 mL	1.3872 mL	2.7745 mL	13.8723 mL
20 mM	0.1387 mL	0.6936 mL	1.3872 mL	6.9362 mL
50 mM	0.0555 mL	0.2774 mL	0.5549 mL	2.7745 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc