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Anti-SLAMF7 Antibody (7U446)
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Catalog No. TMAY-02004
Alias SLAM7, SLAM family member 7, CS1, CRACC, CD319, 19A
Anti-SLAMF7 Antibody (7U446) is a Rabbit antibody targeting SLAMF7. Anti-SLAMF7 Antibody (7U446) can be used in ELISA.
Anti-SLAMF7 Antibody (7U446)
Anti-SLAMF7 Antibody (7U446)
😃Good
Catalog No. TMAY-02004Alias SLAM7, SLAM family member 7, CS1, CRACC, CD319, 19A
Anti-SLAMF7 Antibody (7U446) is a Rabbit antibody targeting SLAMF7. Anti-SLAMF7 Antibody (7U446) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-SLAMF7 Antibody (7U446) is a Rabbit antibody targeting SLAMF7. Anti-SLAMF7 Antibody (7U446) can be used in ELISA. |
| Alias | SLAM7, SLAM family member 7, CS1, CRACC, CD319, 19A |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 7U446 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CRACC / SLAM7 / CD319 (rh CRACC / SLAM7 / CD319; TMPY-01483; NP_067004.3; Met1-Met226). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CRACC / SLAM7 / CD319 Protein (TMPY-01483) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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