Neurotransmitter Receptor Compound Library

Catalog No. L2610

Library Compound List Excel SDF

A neurotransmitter receptor (also known as a neuroreceptor) is a membrane receptor protein that is activated by a neurotransmitter. Chemicals on the outside of the cell, such as a neurotransmitter, can bump into its corresponding receptor in the membrane, bind and trigger other events to occur inside the cell. A neurotransmitter receptor is a class of receptors that specifically binds with neurotransmitters as opposed to other molecules. Neurotransmitter (NT) receptors are located on the surface of neuronal and glial cells.

There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic means that ions can pass through the receptor, whereas metabotropic means that a second messenger inside the cell relays the message (i.e. metabotropic receptors do not have channels). Metabotropic receptors are in fact G protein-coupled receptors. Ionotropic receptors are also called Ligand-gated ion channels and they can be excited by neurotransmitters like glutamate and aspartate. There are several major classes of neurotransmitters: Adrenergic, Dopaminergic, GABAergic, Glutaminergic, Histaminergic, Cholinergic, Opioid, Serotonergic, and Glycinergic.

In the brain, most drug targets consist of signaling proteins that go awry in central nervous system diseases, for example with autism in childhood, schizophrenia in adolescence, or Alzheimer's disease in old age. The aim of drug treatment is to correct the inappropriate behavior of these proteins and restore normal brain function. Understanding the effects of neurotransmitters is extremely important in therapeutics. All psychiatric drugs act by affecting neurotransmitters. Understanding their mechanism of action and adverse effects is key to developing new drugs for neurological diseases.

The TargetMol neurotransmitter receptor compound library contains 1513 CNS receptor ligands, which is ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays, and for routine pharmacological applications.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening；
Targets include 5-HT receptor, AChR, GABA receptor, dopamine receptor,Opiod receptor, Ionotropic Glutamatergic receptor, Metabotropic Glutamatergic receptor, Purinergic receptor, etc.；
Structurally diverse, medicinally active, and cell permeable;
Detailed information about compound structure, target, activity, etc.；
NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

5-HT Receptor (347)

AChR (277)

Dopamine Receptor (219)

Adrenergic Receptor (212)

Histamine Receptor (152)

GABA Receptor (141)

GluR (91)

Opioid Receptor (72)

Adenosine Receptor (72)

AChE (71)

iGluR (68)

NMDAR (63)

Autophagy (56)

Endogenous Metabolite (54)

Apoptosis (40)

Norepinephrine (31)

Serotonin Transporter (28)

Antibacterial (27)

Calcium Channel (24)

Potassium Channel (23)

Parasite (19)

Sodium Channel (18)

Neuropeptide Y Receptor (17)

Endothelin Receptor (17)

P450 (15)

PDE (14)

Influenza Virus (11)

NF-κB (9)

Antibiotic (7)

cholecystokinin (7)

HIV Protease (7)

Antifungal (7)

CaMK (7)

HDAC (6)

Phospholipase (6)

Reactive Oxygen Species (6)

COX (6)

TRP/TRPV Channel (5)

P-gp (5)

TNF (5)

Mitophagy (5)

HCV Protease (5)

Monoamine Transporter (4)

Adenosine deaminase (4)

NO Synthase (4)

Histone Methyltransferase (4)

DNA/RNA Synthesis (4)

Ferroptosis (4)

MAO (4)

ERK (4)

Dehydrogenase (4)

Beta Amyloid (4)

Virus Protease (4)

Sigma receptor (4)

HSV (3)

Chloride channel (3)

Prostaglandin Receptor (3)

Monoamine Oxidase (3)

P2X Receptor (3)

Transferase (3)

Drug Metabolite (3)

Cannabinoid Receptor (3)

BACE (3)

RAAS (3)

Beta-Secretase (3)

GPR (3)

Glucocorticoid Receptor (3)

ABC (3)

Tyrosinase (3)

AMPK (3)

VEGFR (3)

PI3K (3)

Caspase (3)

RSV (2)

Aurora Kinase (2)

mTOR (2)

cAMP (2)

IL Receptor (2)

Lipoxygenase (2)

HER (2)

SARS-CoV (2)

BCL (2)

PPAR (2)

Adenylyl cyclase (2)

NOS (2)

Transaminase (2)

Imidazoline Receptor (2)

Antioxidant (2)

DYRK (2)

Phosphatase (2)

GSK-3 (2)

Melatonin Receptor (2)

ROS (2)

PKA (2)

HBV (2)

MRP (2)

PARP (2)

MEK (2)

Anti-infection (2)

Gamma-secretase (2)

PAFR (2)

GST (1)

Hydroxylase (1)

GluCls (1)

FGFR (1)

p53 (1)

FAK (1)

HIF/HIF Prolyl-Hydroxylase (1)

Microtubule Associated (1)

CRISPR/Cas9 (1)

Reverse Transcriptase (1)

Gap Junction Protein (1)

STAT (1)

Nrf2 (1)

FLT (1)

Syk (1)

HMG-CoA Reductase (1)

NOD (1)

DNA Methyltransferase (1)

Platelet aggregation (1)

Melanin-concentrating Hormone Receptor (MCHR) (1)

Aminopeptidase (1)

OCT (1)

Adiponectin receptor (1)

Annexin A (1)

Immunology/Inflammation related (1)

IAP (1)

Aryl Hydrocarbon Receptor (1)

PKC (1)

Leukotriene Receptor (1)

FXR (1)

Antifolate (1)

Progesterone Receptor (1)

LDL (1)

GTPase (1)

NADPH (1)

Arrestin (1)

Na+/Ca2+ Exchanger (1)

Estrogen/progestogen Receptor (1)

p38 MAPK (1)

Amino Acids and Derivatives (1)

Integrin (1)

Carbonic Anhydrase (1)

CAT (1)

Bcr-Abl (1)

GRK (1)

Trk receptor (1)

Epigenetic Reader Domain (1)

Acyltransferase (1)

MAPK (1)

Akt (1)

EGFR (1)

TGF-beta/Smad (1)

Interleukin (1)

Androgen Receptor (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

DNA (1)

ACK (1)

Raf (1)

PAD (1)

MMP (1)

CCR (1)

Stearoyl-CoA Desaturase (SCD) (1)

Bombesin Receptor (1)

Antifection (1)

Glucosidase (1)

Mitochondrial Metabolism (1)

GlyT (1)

MT Receptor (1)

Fatty Acid Synthase (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty