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TargetMol | Compound Library

Neurotransmitter Receptor Compound Library

Catalog No. L2610

A neurotransmitter receptor (also known as a neuroreceptor) is a membrane receptor protein that is activated by a neurotransmitter. Chemicals on the outside of the cell, such as a neurotransmitter, can bump into its corresponding receptor in the membrane, bind and trigger other events to occur inside the cell. A neurotransmitter receptor is a class of receptors that specifically binds with neurotransmitters as opposed to other molecules. Neurotransmitter (NT) receptors are located on the surface of neuronal and glial cells.

There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic means that ions can pass through the receptor, whereas metabotropic means that a second messenger inside the cell relays the message (i.e. metabotropic receptors do not have channels). Metabotropic receptors are in fact G protein-coupled receptors. Ionotropic receptors are also called Ligand-gated ion channels and they can be excited by neurotransmitters like glutamate and aspartate. There are several major classes of neurotransmitters: Adrenergic, Dopaminergic, GABAergic, Glutaminergic, Histaminergic, Cholinergic, Opioid, Serotonergic, and Glycinergic.

In the brain, most drug targets consist of signaling proteins that go awry in central nervous system diseases, for example with autism in childhood, schizophrenia in adolescence, or Alzheimer's disease in old age. The aim of drug treatment is to correct the inappropriate behavior of these proteins and restore normal brain function. Understanding the effects of neurotransmitters is extremely important in therapeutics. All psychiatric drugs act by affecting neurotransmitters. Understanding their mechanism of action and adverse effects is key to developing new drugs for neurological diseases.

The TargetMol neurotransmitter receptor compound library contains 1660 CNS receptor ligands, which is ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays, and for routine pharmacological applications.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2610

Neurotransmitter Receptor Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Product Description Product Description

  • A unique collection of 1660 neurotransmitter receptor compounds, can be used for HTS and HCS screening;
  • Targets include 5-HT receptor, AChR, GABA receptor, dopamine receptor,Opiod receptor, Ionotropic Glutamatergic receptor, Metabotropic Glutamatergic receptor, Purinergic receptor, etc.;
  • Structurally diverse, medicinally active, and cell permeable;
  • Detailed information about compound structure, target, activity, etc.;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

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Library Customization | TargetMol Library Composition

5-HT Receptor
AChR
Adrenergic Receptor
Dopamine Receptor
Histamine Receptor
GABA Receptor
Adenosine Receptor
GluR
NMDAR
iGluR
Autophagy
Endogenous Metabolite
Norepinephrine
Apoptosis
Serotonin Transporter
Calcium Channel
Sodium Channel
Potassium Channel
Cholinesterase (ChE)
Antibacterial
PDE
Parasite
Cytochromes P450
Influenza Virus
TRP/TRPV Channel
Sigma receptor
HIV Protease
CaMK
Reactive Oxygen Species
NF-κB
HER
HCV Protease
Antibiotic
MAO
HDAC
Antifungal
TNF
Phospholipase
P-gp
P2X Receptor
Opioid Receptor
NO Synthase
Monoamine Transporter
Mitophagy
Lipoxygenase
Histone Methyltransferase
ABC Transporter
Ferroptosis
ERK
Drug Metabolite
DNA/RNA Synthesis
Dehydrogenase
COX
BACE
Virus Protease
VEGFR
Transferase
SARS-CoV
ROS
RAAS
Prostaglandin Receptor
PKA
PI3K
MRP
Monoamine Oxidase
Imidazoline Receptor
GPR
Glucocorticoid Receptor
Chloride channel
Caspase
Cannabinoid Receptor
cAMP
Beta Amyloid
AMPK
Tyrosinase
Transaminase
STAT
PPAR
Platelet aggregation
Phosphatase
PARP
PAFR
NOS
MT Receptor
Melatonin Receptor
MEK
Immunology/Inflammation related
IL Receptor
GSK-3
Gamma-secretase
Adenylyl Cyclase
Acyltransferase
EGFR
Beta-Secretase
Bcl-2 Family
Aurora Kinase
Antioxidant
Anti-infection
Antifection
Trk receptor
transporter
TGF-beta/Smad
Syk
Stearoyl-CoA Desaturase (SCD)
RSV
Reverse Transcriptase
Reductase
Raf
PKC
PAD
p53
p38 MAPK
OCT
NOD
NADPH
Na+/Ca2+ Exchanger
mTOR
MMP
Mitochondrial Metabolism
Microtubule Associated
Melanin-concentrating Hormone Receptor (MCHR)
LTR
Leukotriene Receptor
LDL
Interleukin
Integrin
Indoleamine 2,3-Dioxygenase (IDO)
IAP
Hydroxylase
HSV
HMG-CoA Reductase
HIF/HIF Prolyl-Hydroxylase
HCN Channel
HBV
GTPase
GST
GRK
GlyT
Glucosidase
GluCls
Gap Junction Protein
Adiponectin Receptor
Adenosine Deaminase
ACK1
FXR
FLT
FGFR
Fatty Acid Synthase
FAK
Epigenetic Reader Domain
DYRK
DNA Methyltransferase
DNA
CRISPR/Cas9
CDK
CCR
Carbonic Anhydrase
Bombesin Receptor
Bcr-Abl
ATM/ATR
Aryl Hydrocarbon Receptor
Arrestin
Antifolate
Annexin A
Angiotensin-converting Enzyme (ACE)
Androgen Receptor
Aminopeptidase
Amino Acids and Derivatives
Akt