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TargetMol | Compound Library

Neurotransmitter Receptor Compound Library

Catalog No. L2610

A neurotransmitter receptor (also known as a neuroreceptor) is a membrane receptor protein that is activated by a neurotransmitter. Chemicals on the outside of the cell, such as a neurotransmitter, can bump into its corresponding receptor in the membrane, bind and trigger other events to occur inside the cell. A neurotransmitter receptor is a class of receptors that specifically binds with neurotransmitters as opposed to other molecules. Neurotransmitter (NT) receptors are located on the surface of neuronal and glial cells.

There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic means that ions can pass through the receptor, whereas metabotropic means that a second messenger inside the cell relays the message (i.e. metabotropic receptors do not have channels). Metabotropic receptors are in fact G protein-coupled receptors. Ionotropic receptors are also called Ligand-gated ion channels and they can be excited by neurotransmitters like glutamate and aspartate. There are several major classes of neurotransmitters: Adrenergic, Dopaminergic, GABAergic, Glutaminergic, Histaminergic, Cholinergic, Opioid, Serotonergic, and Glycinergic.

In the brain, most drug targets consist of signaling proteins that go awry in central nervous system diseases, for example with autism in childhood, schizophrenia in adolescence, or Alzheimer's disease in old age. The aim of drug treatment is to correct the inappropriate behavior of these proteins and restore normal brain function. Understanding the effects of neurotransmitters is extremely important in therapeutics. All psychiatric drugs act by affecting neurotransmitters. Understanding their mechanism of action and adverse effects is key to developing new drugs for neurological diseases.

The TargetMol neurotransmitter receptor compound library contains 2120 CNS receptor ligands, which is ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays, and for routine pharmacological applications.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2610

Neurotransmitter Receptor Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Product Description Product Description

  • A unique collection of 2120 neurotransmitter receptor compounds, can be used for HTS and HCS screening;
  • Targets include 5-HT receptor, AChR, GABA receptor, dopamine receptor,Opiod receptor, Ionotropic Glutamatergic receptor, Metabotropic Glutamatergic receptor, Purinergic receptor, etc.;
  • Structurally diverse, medicinally active, and cell permeable;
  • Detailed information about compound structure, target, activity, etc.;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

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Library Customization | TargetMol Library Composition

5-HT Receptor
AChR
Adrenergic Receptor
Dopamine Receptor
Histamine Receptor
GABA Receptor
GluR
NMDAR
Adenosine Receptor
iGluR
Opioid Receptor
Endogenous Metabolite
Cannabinoid Receptor
Autophagy
Apoptosis
Norepinephrine
P2X Receptor
Neurokinin receptor
Serotonin Transporter
Calcium Channel
Potassium Channel
Sodium Channel
Antibacterial
P2Y Receptor
Cholinesterase (ChE)
Cytochromes P450
PDE
Parasite
Influenza Virus
NF-κB
TRP/TRPV Channel
HIV Protease
Sigma receptor
Antibiotic
GPCR
Ferroptosis
Antifungal
Mitophagy
Reactive Oxygen Species
CaMK
HCV Protease
Dehydrogenase
ERK
DNA/RNA Synthesis
HDAC
Virus Protease
MAO
Monoamine Transporter
cAMP
Akt
Phospholipase
TNF
Histone Methyltransferase
BACE
PPAR
Caspase
Drug Metabolite
ABC Transporter
Lipoxygenase
COX
P-gp
Acyltransferase
SARS-CoV
Beta Amyloid
AMPK
Monoamine Oxidase
NO Synthase
Transferase
Transaminase
PI3K
Antioxidant
Arrestin
RAAS
PKA
MRP
VEGFR
Glucocorticoid Receptor
PAFR
ROS
FAAH
HSV
IL Receptor
Prostaglandin Receptor
Bcl-2 Family
Anti-infection
Imidazoline Receptor
Chloride channel
Adenylyl Cyclase
NOS
Amino Acids and Derivatives
DYRK
Phosphatase
GSK-3
Melatonin Receptor
PARP
Immunology/Inflammation related
Gamma-secretase
MT Receptor
Aurora Kinase
Epigenetic Reader Domain
TGF-beta/Smad
EGFR
Beta-Secretase
GluCls
RSV
STAT
MEK
Platelet aggregation
HMG-CoA Reductase
Microtubule Associated
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
Melanin-concentrating Hormone Receptor (MCHR)
MicroRNA
Carbonic Anhydrase
Integrin
p38 MAPK
Estrogen/progestogen Receptor
LTR
Na+/Ca2+ Exchanger
Reductase
NADPH
PERK
GTPase
Progesterone Receptor
OCT
HBV
Rho
Antifolate
Nucleoside Antimetabolite/Analog
FXR
Leukotriene Receptor
PKC
Aryl Hydrocarbon Receptor
IAP
Topoisomerase
Annexin A
Adiponectin Receptor
Bcr-Abl
LDL
GRK
CDK
Raf
GlyT
Na-K-Cl cotransporter
Mitochondrial Metabolism
Glucosidase
Antifection
HCN Channel
Fatty Acid Synthase
Bombesin Receptor
Stearoyl-CoA Desaturase (SCD)
CCR
ACK1
Angiotensin-converting Enzyme (ACE)
MMP
PAD
DNA
Indoleamine 2,3-Dioxygenase (IDO)
mTOR
Androgen Receptor
Interleukin
Trk receptor
Aminopeptidase
transporter
IκB/IKK
ATM/ATR
GST
Reverse Transcriptase
CRISPR/Cas9
Hydroxylase
Adenosine Deaminase
FGFR
Gap Junction Protein
FLT
Syk
NOD
DNA Methyltransferase
FAK
p53