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KY-226

Name: KY-226
Brand: TargetMol
SKU: T7704
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T7704Cas No. 1621673-53-7

KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,)

KY-226

🥰Excellent

Purity: 99.4%

Catalog No. T7704Cas No. 1621673-53-7

KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,)

Pack Size	Price	Availability
1 mg	$46	In Stock
5 mg	$122	In Stock
10 mg	$179	In Stock
25 mg	$297	In Stock
50 mg	$463	In Stock
100 mg	$742	In Stock
1 mL x 10 mM (in DMSO)	$128	In Stock

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Purity:99.4%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,)
Targets&IC50	PTP1B:0.25 μM
In vivo	In db/db mice, the oral administration of KY-226 (10 and 30 mg/kg/day, 4 weeks) significantly reduced plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain, while pioglitazone exerted similar effects with increases in body weight gain.?KY-226 attenuated plasma glucose elevations in the oral glucose tolerance test.?KY-226 also increased pIR and phosphorylated Akt in the liver and femoral muscle.?In high-fat diet-induced obese mice, the oral administration of KY-226 (30 and 60 mg/kg/day, 4 weeks) decreased body weight gain, food consumption, and fat volume gain with increases in phosphorylated STAT3 in the hypothalamus.

Chemical Properties

Molecular Weight	481.67
Formula	C₂₇H₃₁NO₃S₂
Cas No.	1621673-53-7
Smiles	CCCCCCS(=O)(=O)NC(=O)c1ccc(CSCc2ccc(cc2)-c2ccccc2)cc1
Relative Density.	1.186 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (51.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0761 mL	10.3806 mL	20.7611 mL	103.8055 mL
5 mM	0.4152 mL	2.0761 mL	4.1522 mL	20.7611 mL
10 mM	0.2076 mL	1.0381 mL	2.0761 mL	10.3806 mL
20 mM	0.1038 mL	0.5190 mL	1.0381 mL	5.1903 mL
50 mM	0.0415 mL	0.2076 mL	0.4152 mL	2.0761 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc