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USP30 inhibitor 18

Name: USP30 inhibitor 18
Brand: TargetMol
SKU: T36682
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36682Cas No. 2242582-40-5

USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.

USP30 inhibitor 18

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Purity: 99.85%

Catalog No. T36682Cas No. 2242582-40-5

USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	In Stock	In Stock
5 mg	$313	In Stock	In Stock
10 mg	$497	In Stock	In Stock
25 mg	$793	In Stock	In Stock
50 mg	$1,130	In Stock	In Stock
100 mg	$1,520	In Stock	In Stock
500 mg	$2,970	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$343	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

Resource Download

COA LCMS HNMR

Product Introduction

USP30 inhibitor 18 AI Summary

USP30 inhibitor 18 demonstrates potent bioactivity as an inhibitor of USP30, exhibiting an IC50 value of approximately 17.0 to 20.0 nM. The inhibitory activity is evaluated using a fluorescence-based assay with ubiquitin-rhodamine 110 (or Ubiquitin-Rhodamine110-Glycine) as the substrate. The assay protocol includes a preincubation period of 15 minutes, followed by the addition of the substrate and measurement after a 2-hour incubation period..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.
Targets&IC50	USP30:0.02 μM

Chemical Properties

Molecular Weight	497.58
Formula	C₂₆H₂₈FN₃O₄S
Cas No.	2242582-40-5
Smiles	CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccc(F)cc2)cc1
Relative Density.	1.278 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (241.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0097 mL	10.0486 mL	20.0973 mL	100.4864 mL
5 mM	0.4019 mL	2.0097 mL	4.0195 mL	20.0973 mL
10 mM	0.2010 mL	1.0049 mL	2.0097 mL	10.0486 mL
20 mM	0.1005 mL	0.5024 mL	1.0049 mL	5.0243 mL
50 mM	0.0402 mL	0.2010 mL	0.4019 mL	2.0097 mL
100 mM	0.0201 mL	0.1005 mL	0.2010 mL	1.0049 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc