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p-Aminophenylmercuric acetate

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Catalog No. T72149Cas No. 6283-24-5

p-Aminophenylmercuric acetate (APMA) is an organic mercury compound and thiol-blocking agent commonly employed as an activator of MMPs (matrix metalloproteinases), capable of modulating cysteine-zinc ion interactions. APMA also induces platelet aggregation activation/inhibition in a dose-dependent manner.

p-Aminophenylmercuric acetate

p-Aminophenylmercuric acetate

🥰Excellent
Purity: 98.32%
Catalog No. T72149Cas No. 6283-24-5
p-Aminophenylmercuric acetate (APMA) is an organic mercury compound and thiol-blocking agent commonly employed as an activator of MMPs (matrix metalloproteinases), capable of modulating cysteine-zinc ion interactions. APMA also induces platelet aggregation activation/inhibition in a dose-dependent manner.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mL x 10 mM (in DMSO)$48-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:98.32%
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Product Introduction

Bioactivity
Description
p-Aminophenylmercuric acetate (APMA) is an organic mercury compound and thiol-blocking agent commonly employed as an activator of MMPs (matrix metalloproteinases), capable of modulating cysteine-zinc ion interactions. APMA also induces platelet aggregation activation/inhibition in a dose-dependent manner.
In vitro
Methods: p-Aminophenylmercuric acetate (50-100μM, 1 hour) was used to treat wild-type (WT) and ADAM-deficient cell lines, and BTC levels in CM and cell lysates were quantified by ELISA.
Results: p-Aminophenylmercuric acetate (50μM) significantly increased the release of the 26-28kDa BTC extracellular domain in CM, reduced the 40kDa pro-BTC form in cell lysates, and increased the 12kDa BTC cytoplasmic residue. [1]
Chemical Properties
Molecular Weight351.75
FormulaC8H9HgNO2
Cas No.6283-24-5
SmilesO=C(O[Hg]C1=CC=C(N)C=C1)C
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 80 mg/mL (227.43 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.38 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8429 mL14.2146 mL28.4293 mL142.1464 mL
5 mM0.5686 mL2.8429 mL5.6859 mL28.4293 mL
10 mM0.2843 mL1.4215 mL2.8429 mL14.2146 mL
20 mM0.1421 mL0.7107 mL1.4215 mL7.1073 mL
50 mM0.0569 mL0.2843 mL0.5686 mL2.8429 mL
100 mM0.0284 mL0.1421 mL0.2843 mL1.4215 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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