Patchouli alcohol (Patchoulol) is a naturally occurring tricyclic sesquiterpenoid found in patchouli oil. It is a key bioactive component known for its immunomodulatory, anti-inflammatory, antioxidant, antitumor, antibacterial, anti-atherosclerotic, antiemetic, and sedative properties.

METHODS: H. pylori-infected GES-1 cells were treated with Patchouli alcohol (5-20 µg/mL) for 24 h. Apoptosis was detected by flow cytometry.
RESULTS: Patchouli alcohol treatment significantly reduced H. pylori-induced apoptosis. [1]
METHODS: H. pylori-infected GES-1 cells were treated with Patchouli alcohol (5-20 µg/mL) for 24 h, and cytokine levels were measured by ELISA.
RESULTS: 5-20 µg/mL Patchouli alcohol treatment significantly reduced the production of TNF-α and MCP-1. [1]

METHODS: To study the effect on H. pylori-associated gastritis, Patchouli alcohol (5-20 mg/kg) was administered orally to H. pylori-infected mice once daily for two weeks.
RESULTS: Patchouli alcohol treatment increased SH-NP content and CAT activity, and significantly protected the gastric mucosa from H. pylori-induced damage. [1]