Shopping Cart
- Remove All
Your shopping cart is currently empty
5-HT3 antagonist 5
🥰Excellent
Catalog No. T9846Cas No. 901599-43-7
5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound that acts as a 5-HT3 receptor antagonist, counteracting 5-HT3 agonist and 2-methyl-5-HT, and demonstrating an anti-depressant effect in mice [1].
5-HT3 antagonist 5
🥰Excellent
Purity: 99.84%
Catalog No. T9846Cas No. 901599-43-7
5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound that acts as a 5-HT3 receptor antagonist, counteracting 5-HT3 agonist and 2-methyl-5-HT, and demonstrating an anti-depressant effect in mice [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $44 | In Stock | |
| 10 mg | $68 | In Stock | |
| 25 mg | $138 | In Stock | |
| 50 mg | $226 | In Stock | |
| 100 mg | $323 | In Stock | |
| 200 mg | $413 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View MoreBatch Information
Select Batch
Purity:99.84%
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
| Description | 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound that acts as a 5-HT3 receptor antagonist, counteracting 5-HT3 agonist and 2-methyl-5-HT, and demonstrating an anti-depressant effect in mice [1]. |
| In vitro | Compound 4c, a 5-HT3 antagonist, demonstrates effective antagonism against the 5-HT3 receptor in the longitudinal muscle myenteric plexus of the guinea pig ileum. This activity is observed when challenged with the 5-HT3 agonist, 2-methyl-5-HT, manifesting a pA2 value of 5 [1]. |
| In vivo | Compound 4c, a 5-HT3 antagonist administered at 1 mg/kg intraperitoneally as a single dose, effectively reduced immobility duration, demonstrating an antidepressant effect in Forced Swim Test (FST) mice [1]. This experiment utilized Swiss albino mice weighing 23 ± 2 g [1]. Despite its significant effect on immobility, compound 4c did not alter the spontaneous locomotor activity in these animals, indicating its specificity in exhibiting the antidepressant effect without affecting general locomotion. |
| Molecular Weight | 279.29 |
| Formula | C16H13N3O2 |
| Cas No. | 901599-43-7 |
| Smiles | COc1ccc(NC(=O)c2cnc3ccccc3n2)cc1 |
| Relative Density. | 1.312 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy 5-HT3 antagonist 5 | purchase 5-HT3 antagonist 5 | 5-HT3 antagonist 5 cost | order 5-HT3 antagonist 5 | 5-HT3 antagonist 5 chemical structure | 5-HT3 antagonist 5 in vivo | 5-HT3 antagonist 5 in vitro | 5-HT3 antagonist 5 formula | 5-HT3 antagonist 5 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.