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STING Agonist 1a
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Catalog No. T38160 Copy Product Info
Purity: 98.07%
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STING Agonist 1a is a specific STING agonist with interferon-inducing activity, offering potential applications in antiviral and antitumor research.
Cas No. 652142-94-4
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $73 | - | In Stock | |
| 5 mg | $289 | - | In Stock | |
| 10 mg | $548 | - | In Stock | |
| 25 mg | $1,090 | - | In Stock | |
| 50 mg | $1,970 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:98.07%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | STING Agonist 1a is a specific STING agonist with interferon-inducing activity, offering potential applications in antiviral and antitumor research. |
| In vitro | Methods: Human myeloid leukemia monocytes (THP-1) were used as experimental cells. Cells were treated with 0–100 μM STING Agonist 1a for 6 hours, and the mRNA expression of inflammation- and interferon-related genes was detected, along with an assessment of cytotoxicity. Additionally, cells were treated with 50 μM STING Agonist 1a for 2 hours, and the phosphorylation levels of STING, TBK1, and IRF3 proteins were detected; Compound activation activity was determined via SEAP assays, and EC₅₀ values were compared with those of 2'3'-cGAMP. Results: STING Agonist 1a dose-dependently upregulated the mRNA expression of IFNβ, CXCL-10, and IL-6 in THP1 cells within the 0–100 μM range, with no significant cytotoxicity observed at a concentration of 100 μM [1]. Treatment of THP1 cells with 50 μM STING Agonist 1a for 2 h significantly promoted the phosphorylation and activation of STING, TBK1, and IRF3. SEAP activity assays showed that STING Agonist 1a activated SEAP in a dose-dependent manner, with an EC₅₀ of 16.77 μM; the positive control 2'3'-cGAMP had an EC₅₀ of 9.212 μM [1]. |
| Molecular Weight | 396.23 |
| Formula | C19H11Cl2N5O |
| Cas No. | 652142-94-4 |
| Smiles | ClC1=NC=2C=CC=CC2N3C1=NN=C3C=4C=C5C=C(OC)C=CC5=NC4Cl |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | PBS (pH 7.2): Slightly soluble DMF: Slightly soluble DMSO: 4 mg/mL (10.1 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: STING Agonist 1a chemical structure | STING Agonist 1a in vitro | STING Agonist 1a formula | STING Agonist 1a molecular weight
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