Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SAHA-OH, a selective HDAC6 inhibitor with an IC50 of 23 nM, exhibits a 10- to 47-fold greater selectivity for HDAC6 over HDACs 1, 2, 3, and 8. It demonstrates anti-inflammatory effects and reduces macrophage apoptosis [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | SAHA-OH, a selective HDAC6 inhibitor with an IC50 of 23 nM, exhibits a 10- to 47-fold greater selectivity for HDAC6 over HDACs 1, 2, 3, and 8. It demonstrates anti-inflammatory effects and reduces macrophage apoptosis [1]. |
Targets&IC50 | HDAC6:23 nM, HDAC1:237 nM, HDAC3:359 nM, HDAC2:399 nM, HDAC8:1070 nM |
In vitro | SAHA-OH, at concentrations ranging from 0.67 to 10.76 μM over a period of 51 hours, demonstrates inhibitory effects on bone marrow macrophages [1]. When applied to bone marrow-derived macrophages (BMMØs) at 0.01 μM for 3 hours, SAHA-OH significantly reduces the secretion of cytokines such as IL-6, TNFα, IFNβ, IL-1β, IL-10, MCP-1 (CCL2), and GROα (CXCL1) [1]. Additionally, a 10 μM SAHA-OH treatment for either 4 or 9 hours results in increased acetylation of cytoplasmic α-tubulin and nuclear histone H3 [1]. At dosages up to 30 μM, a 3-hour treatment with SAHA-OH effectively decreases apoptosis in macrophages and reduces death in B cells [1]. |
In vivo | SAHA-OH, administered through intraperitoneal injection at a dose of 50 mg/kg in a single dose, mitigates splenic damage and diminishes the levels of proinflammatory cytokines in plasma in a mouse model of LPS-induced endotoxemia [1]. |
Molecular Weight | 294.35 |
Formula | C15H22N2O4 |
CAS No. | 2857098-30-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SAHA-OH 2857098-30-5 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC inhibitor inhibit