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Anti-4EBP1 Antibody-PE (2W533)
🥰Excellent
Catalog No. TMAY-00089P
Anti-4EBP1 Antibody-PE (2W533) is a PE-conjugated Mouse antibody targeting 4EBP1. Anti-4EBP1 Antibody-PE (2W533) can be used in FCM.
Anti-4EBP1 Antibody-PE (2W533)
Anti-4EBP1 Antibody-PE (2W533)
🥰Excellent
Catalog No. TMAY-00089P
Anti-4EBP1 Antibody-PE (2W533) is a PE-conjugated Mouse antibody targeting 4EBP1. Anti-4EBP1 Antibody-PE (2W533) can be used in FCM.
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Chemical Properties
| Description | Anti-4EBP1 Antibody-PE (2W533) is a PE-conjugated Mouse antibody targeting 4EBP1. Anti-4EBP1 Antibody-PE (2W533) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 2W533 |
| Reactivity | Human |
| Verified Activity | Profile of anti-4EBP1 reactivity on HepG2 cells analyzed by flow cytometry. |
| Application | FCM |
| Recommended Dose | 2 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human 4E-BP1 / EIF4EBP1 (rh 4E-BP1 / EIF4EBP1; TMPY-01769; NP_004086.1; Ser2-Ile118) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcription factor activating transcription factor-4 (ATF4), a master regulator of gene expression in stress responses. 4E-BP1 is characterized by its capacity to bind specifically to eIF4E and inhibit its interaction with eIF4G. Phosphorylation of 4E-BP1 regulates eIF4E availability, and therefore, cap-dependent translation, in cell stress. Binding of eIF4E to eIF4G is inhibited in a competitive manner by 4E-BP1. Phosphorylation of 4E-BP1 decreases the affinity of this protein for eIF4E, thus favouring the binding of eIF4G and enhancing translation. 4E-BP1 is important for beta-cell survival under endoplasmic reticulum (ER) stress. 4E-BP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Recently, 4E-BP1 was found to be a key factor, which converges several oncogenic signals, phosphorylates the molecules, and drives the downstream proliferative signals. Recent studies showed that high expression of phosphorylated 4E-BP-1 (p-4E-BP1) is associated with poor prognosis, tumor progression, or nodal metastasis in different human cancers. |
| Conjucates | PE |
| Others Formats | Unconjugated/FITC |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Human 4E-BP1 / EIF4EBP1 protein (TMPY-01769) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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