Enterocin (Vulgamycin) is a bacteriocin and polyketide antibiotic produced by Enterococcus spp. bacteria that is readily degraded by proteolytic hydrolysis in the gastrointestinal tract and is capable of controlling foodborne pathogens such as L. monocytogenes, Listeria, and Bacillus through human consumption. and and Bacillus.

Enterocin is a very special structure with a unique and highly oxidized three-ring cage core skeleton with an α-pyrone unit and a benzyl group. The biosynthetic pathway of this compound begins with the assembly of the benzoic acid unit by a ligase, followed by seven iterative elongation steps mediated by type II polyketide synthases via a decarboxylative Claisen condensation with malonyl-CoA. Of particular interest is the oxidation of the C4 methylene group catalyzed by flavoproteins, which further triggers a Favorsky-like rearrangement and two intramolecular aldol condensations to build the three-ring cage skeleton.