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GSK4418959

🥰Excellent
Catalog No. T204089Cas No. 3064599-36-3
Alias IDE275, IDE 275, GSK 4418959

GSK4418959 (IDE275) is a non-covalent, reversible, selective, and orally active inhibitor of the Werner syndrome helicase (WRN helicase). GSK4418959 inhibits both ATPase and DNA unwinding activities of WRN helicase in an ATP-competitive manner. GSK4418959 is a valuable chemical tool for the study of microsatellite instability-high (MSI-H) cancers, where WRN helicase plays an essential role in maintaining genomic stability.

GSK4418959

GSK4418959

🥰Excellent
Purity: 99.141%
Catalog No. T204089Alias IDE275, IDE 275, GSK 4418959Cas No. 3064599-36-3
GSK4418959 (IDE275) is a non-covalent, reversible, selective, and orally active inhibitor of the Werner syndrome helicase (WRN helicase). GSK4418959 inhibits both ATPase and DNA unwinding activities of WRN helicase in an ATP-competitive manner. GSK4418959 is a valuable chemical tool for the study of microsatellite instability-high (MSI-H) cancers, where WRN helicase plays an essential role in maintaining genomic stability.
Pack SizePriceAvailabilityQuantity
1 mg$413In Stock
5 mg$987In Stock
10 mg$1,590In Stock
25 mg$2,960In Stock
50 mg$4,550In Stock
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Purity:99.141%
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Product Introduction

Bioactivity
Description
GSK4418959 (IDE275) is a non-covalent, reversible, selective, and orally active inhibitor of the Werner syndrome helicase (WRN helicase). GSK4418959 inhibits both ATPase and DNA unwinding activities of WRN helicase in an ATP-competitive manner. GSK4418959 is a valuable chemical tool for the study of microsatellite instability-high (MSI-H) cancers, where WRN helicase plays an essential role in maintaining genomic stability.
In vivo
GSK4418959 (IDE275) induces tumor regression and activates DNA damage response (DDR) markers in several MSI-H CDX and PDX models across diverse tumor types, including CRC, endometrial, and gastric cancers with varying oncogenic drivers and tumor suppressor mutations, while sparing MSS models[1].
SynonymsIDE275, IDE 275, GSK 4418959
Chemical Properties
Molecular Weight646.65
FormulaC31H30F4N4O5S
Cas No.3064599-36-3
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (123.71 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5464 mL7.7322 mL15.4643 mL77.3216 mL
5 mM0.3093 mL1.5464 mL3.0929 mL15.4643 mL
10 mM0.1546 mL0.7732 mL1.5464 mL7.7322 mL
20 mM0.0773 mL0.3866 mL0.7732 mL3.8661 mL
50 mM0.0309 mL0.1546 mL0.3093 mL1.5464 mL
100 mM0.0155 mL0.0773 mL0.1546 mL0.7732 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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