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Tpl2 Kinase Inhibitor 1 hydrochloride
🥰Excellent
Catalog No. T211946Cas No. 2934185-09-6
Tpl2 Kinase Inhibitor 1 hydrochloride is a selective Tpl2 inhibitor with an IC50 value of 50 nM. Tpl2 encompasses COT kinase and MAP3K8, and this inhibitor is applicable for research related to inflammatory responses and certain types of cancer.
Tpl2 Kinase Inhibitor 1 hydrochloride
🥰Excellent
Catalog No. T211946Cas No. 2934185-09-6
Tpl2 Kinase Inhibitor 1 hydrochloride is a selective Tpl2 inhibitor with an IC50 value of 50 nM. Tpl2 encompasses COT kinase and MAP3K8, and this inhibitor is applicable for research related to inflammatory responses and certain types of cancer.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tpl2 Kinase Inhibitor 1 hydrochloride is a selective Tpl2 inhibitor with an IC50 value of 50 nM. Tpl2 encompasses COT kinase and MAP3K8, and this inhibitor is applicable for research related to inflammatory responses and certain types of cancer. |
| Targets&IC50 | p38:180 μM |
| In vitro | Tpl2 (Cot/MAP3K8) is a serine/threonine kinase within the MAP3K family, acting upstream of MEK in the ERK pathway. The Cancer Osaka thyroid (COT) kinase (Tpl2) plays a critical role as a regulator of pro-inflammatory cytokines in macrophages. Tpl2 Kinase Inhibitor 1 (Compound 2p) hydrochloride also inhibits MK2 and p38 with IC₅₀ values of 110 μM and 180 μM in A431 cells, respectively. This inhibitor suppresses the production of TNF-a in lipopolysaccharide-induced human primary monocytes and human whole blood, with IC₅₀ values of 0.7 μM and 8.5 μM, respectively. |
| Molecular Weight | 441.29 |
| Formula | C21H15Cl2FN6 |
| Cas No. | 2934185-09-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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