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Anti-PD-L1 Antibody (2L342)
(Synonyms: PD-L1B7 homolog 1, PD-L1, PDL1, PDCD1LG1, PDCD1L1, CD274, B7-H1, B7H1, B7-H) Copy Product Info
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Synonyms: PD-L1B7 homolog 1, PD-L1, PDL1, PDCD1LG1, PDCD1L1, CD274, B7-H1, B7H1, B7-H
Catalog No. TMAH-00870 Copy Product Info
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Anti-PD-L1 Antibody (2L342) is a Mouse antibody targeting PD-L1. Anti-PD-L1 Antibody (2L342) can be used in ELISA,FCM,IF,IHC,WB.
Anti-PD-L1 Antibody
(2L342)
(2L342)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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| Description | Anti-PD-L1 Antibody (2L342) is a Mouse antibody targeting PD-L1. Anti-PD-L1 Antibody (2L342) can be used in ELISA,FCM,IF,IHC,WB. |
| Synonyms | PD-L1B7 homolog 1, PD-L1, PDL1, PDCD1LG1, PDCD1L1, CD274, B7-H1, B7H1, B7-H |
| Ig Type | IgG2b |
| Clone | 2L342 |
| Reactivity | Human |
| Application | |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Endomembrane system; Single-pass type I membrane protein. |
| Tissue Specificity | Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Purity | >95% |
| Research Background | Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Programmed cell death 1 ligand 1 Protein (19-238AA) |
| Antigen Species | Human |
| Gene Name | CD274 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Immunology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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