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EDA2R Protein, Mouse, Recombinant (His)
(Synonyms: X-linked ectodysplasin-A2 receptor, XEDAR, Tumor necrosis factor receptor superfamily member XEDAR, Tumor necrosis factor receptor superfamily member 27, TNFRSF27, EDAR2, EDA-A2R, EDAA2R, EDA-A2 receptor, Ectodysplasin A2 receptor) Copy Product InfoSynonyms: X-linked ectodysplasin-A2 receptor, XEDAR, Tumor necrosis factor receptor superfamily member XEDAR, Tumor necrosis factor receptor superfamily member 27, TNFRSF27, EDAR2, EDA-A2R, EDAA2R, EDA-A2 receptor, Ectodysplasin A2 receptor
Catalog No. TMPJ-01211 Copy Product Info
Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA‑A2 dependent apoptosis. Its transcription is directly induced by p53, and it mediated cell death is p53 dependent. it is down‑regulated in breast, colon, and lung cancers, particularly in cases with p53 mutations. It also plays a role in EDA‑A2 induced skeletal muscle degeneration and osteoblast differentiation. Mutations in the EDA gene are associated with the X-linked form of Hypohidrotic Ectodermal Dysplasia (HED), a disease typically characterized by abnormal hair, teeth and sweat glands.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $58 | 7-10 days | 7-10 days | |
| 10 μg | $91 | 7-10 days | 7-10 days | |
| 20 μg | $133 | 7-10 days | 7-10 days | |
| 50 μg | $222 | 7-10 days | 7-10 days | |
| 100 μg | $397 | 7-10 days | 7-10 days | |
| 200 μg | $715 | 7-10 days | 7-10 days | |
| 500 μg | $1,570 | 7-10 days | 7-10 days | |
| 1 mg | $2,230 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA‑A2 dependent apoptosis. Its transcription is directly induced by p53, and it mediated cell death is p53 dependent. it is down‑regulated in breast, colon, and lung cancers, particularly in cases with p53 mutations. It also plays a role in EDA‑A2 induced skeletal muscle degeneration and osteoblast differentiation. Mutations in the EDA gene are associated with the X-linked form of Hypohidrotic Ectodermal Dysplasia (HED), a disease typically characterized by abnormal hair, teeth and sweat glands. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-6xHis |
| Accession Number | Q8BX35 |
| Amino Acid | Met1-Thr138 |
| Construction | Met1-Thr138 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | X-linked ectodysplasin-A2 receptor, XEDAR, Tumor necrosis factor receptor superfamily member XEDAR, Tumor necrosis factor receptor superfamily member 27, TNFRSF27, EDAR2, EDA-A2R, EDAA2R, EDA-A2 receptor, Ectodysplasin A2 receptor |
| Research Background |
| Molecular Weight | 26 KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: EDA2R Protein, Mouse, Recombinant (His) chemical structure | EDA2R Protein, Mouse, Recombinant (His) molecular weight
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