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CDK8-IN-1

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Catalog No. T10740Cas No. 1629633-48-2

CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).

CDK8-IN-1

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Purity: 98.48%

Catalog No. T10740Cas No. 1629633-48-2

CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	In Stock
5 mg	$228	In Stock	In Stock
10 mg	$328	In Stock	In Stock
25 mg	$553	In Stock	In Stock
50 mg	$745	In Stock	In Stock
100 mg	$993	-	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.48%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).
Targets&IC50	CDK8:3 nM
In vivo	CDK8-IN-1 exhibits low systemic clearance, excellent exposure, and oral bioavailability, with a tmax of 0.25 h (p.o.). The AUC values are 9378 (i.v.) and 25952 (p.o.), while the mean Cmax values are 9940 μg/L (i.v.) and 12740 μg/L (p.o.) respectively[1].

Chemical Properties

Molecular Weight	255.2
Formula	C₁₁H₈F₃N₃O
Cas No.	1629633-48-2
Smiles	NC(=O)c1[nH]cc(c1C(F)(F)F)-c1ccncc1
Relative Density.	1.429 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (352.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9185 mL	19.5925 mL	39.1850 mL	195.9248 mL
5 mM	0.7837 mL	3.9185 mL	7.8370 mL	39.1850 mL
10 mM	0.3918 mL	1.9592 mL	3.9185 mL	19.5925 mL
20 mM	0.1959 mL	0.9796 mL	1.9592 mL	9.7962 mL
50 mM	0.0784 mL	0.3918 mL	0.7837 mL	3.9185 mL
100 mM	0.0392 mL	0.1959 mL	0.3918 mL	1.9592 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc