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AZ31

🥰Excellent
Catalog No. T19671Cas No. 2088113-98-6
Alias AZ-31, AZ 31

AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK family selectivity, and pan-kinase selectivity.AZ31 is a potent in vitro radiosensitizer that can be used for cancer research.

AZ31

AZ31

🥰Excellent
Purity: 98.1%
Catalog No. T19671Alias AZ-31, AZ 31Cas No. 2088113-98-6
AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK family selectivity, and pan-kinase selectivity.AZ31 is a potent in vitro radiosensitizer that can be used for cancer research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$38In StockIn Stock
5 mg$64In StockIn Stock
10 mg$103In StockIn Stock
25 mg$173In StockIn Stock
50 mg$259In StockIn Stock
1 mL x 10 mM (in DMSO)$77In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:98.1%
ee:100%
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Product Introduction

Bioactivity
Description
AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK family selectivity, and pan-kinase selectivity.AZ31 is a potent in vitro radiosensitizer that can be used for cancer research.
Targets&IC50
ATM (oral):1.2 nM, ATM:46 nM
In vitro
AZ31 (0.3-3 μM ; 1 h) modulates the phosphorylation of a range of ATM targets.[2]
AZ31 (10 μM ; 1 h) influences the stabilization of p53 in H2228 lung cancer cells post-radiation.[2]
In vivo
AZ31 (50-100 mg/kg ; p.o. twice daily) exhibits limited penetration into the brain.[2]
SynonymsAZ-31, AZ 31
Chemical Properties
Molecular Weight420.5
FormulaC24H28N4O3
Cas No.2088113-98-6
SmilesN([C@@H](C)C1CCOCC1)C=2C3=C(N=CC2C(N)=O)C=CC(=C3)C=4C=CC(COC)=NC4
Relative Density.1.234 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (59.45 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3781 mL11.8906 mL23.7812 mL118.9061 mL
5 mM0.4756 mL2.3781 mL4.7562 mL23.7812 mL
10 mM0.2378 mL1.1891 mL2.3781 mL11.8906 mL
20 mM0.1189 mL0.5945 mL1.1891 mL5.9453 mL
50 mM0.0476 mL0.2378 mL0.4756 mL2.3781 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

AZ31ATRATM
Related Tags: buy AZ31 | purchase AZ31 | AZ31 cost | order AZ31 | AZ31 chemical structure | AZ31 in vivo | AZ31 in vitro | AZ31 formula | AZ31 molecular weight
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