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RIPK-IN-4

Name: RIPK-IN-4
Brand: TargetMol
SKU: T16755
Rating: 4.5 (1 reviews)

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Catalog No. T16755Cas No. 2141969-56-2

RIPK-IN-4 is a highly effective and selective small-molecule inhibitor of receptor-interacting protein kinase 2 (RIPK2) that demonstrates potent biochemical activity with an IC50 value of 3 nM, and it is further distinguished by excellent oral bioavailability, making it a valuable research tool for investigating RIPK2-mediated signaling pathways, innate immune responses, and inflammatory disease mechanisms in both in vitro and in vivo experimental systems.

RIPK-IN-4

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Catalog No. T16755Cas No. 2141969-56-2

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,430	8-10 weeks	8-10 weeks
50 mg	$1,860	8-10 weeks	8-10 weeks
100 mg	$2,820	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	RIPK-IN-4 is a highly effective and selective small-molecule inhibitor of receptor-interacting protein kinase 2 (RIPK2) that demonstrates potent biochemical activity with an IC50 value of 3 nM, and it is further distinguished by excellent oral bioavailability, making it a valuable research tool for investigating RIPK2-mediated signaling pathways, innate immune responses, and inflammatory disease mechanisms in both in vitro and in vivo experimental systems.
Targets&IC50	RIPK2:3 nM
In vitro	Method: Liver microsomal stability assays were conducted using mouse, rat, and human liver microsomes. Result: RIPK-IN-4 exhibited liver microsomal extraction ratios of 0.59 in mice, 0.45 in rats, and 0.39 in humans[1].

Chemical Properties

Molecular Weight	392.45
Formula	C₁₈H₂₁FN₄O₃S
Cas No.	2141969-56-2
Smiles	O=S(=O)(C1=CN2C(=NC=C2C=3C=C(F)N=C(N)C3)C=C1OCC)C(C)(C)C
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 24 mg/mL (61.15 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5481 mL	12.7405 mL	25.4810 mL	127.4048 mL
5 mM	0.5096 mL	2.5481 mL	5.0962 mL	25.4810 mL
10 mM	0.2548 mL	1.2740 mL	2.5481 mL	12.7405 mL
20 mM	0.1274 mL	0.6370 mL	1.2740 mL	6.3702 mL
50 mM	0.0510 mL	0.2548 mL	0.5096 mL	2.5481 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc