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RIPK-IN-4

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Catalog No. T16755Cas No. 2141969-56-2

RIPK-IN-4 is a highly effective and selective small-molecule inhibitor of receptor-interacting protein kinase 2 (RIPK2) that demonstrates potent biochemical activity with an IC50 value of 3 nM, and it is further distinguished by excellent oral bioavailability, making it a valuable research tool for investigating RIPK2-mediated signaling pathways, innate immune responses, and inflammatory disease mechanisms in both in vitro and in vivo experimental systems.

RIPK-IN-4

RIPK-IN-4

😃Good
Catalog No. T16755Cas No. 2141969-56-2
RIPK-IN-4 is a highly effective and selective small-molecule inhibitor of receptor-interacting protein kinase 2 (RIPK2) that demonstrates potent biochemical activity with an IC50 value of 3 nM, and it is further distinguished by excellent oral bioavailability, making it a valuable research tool for investigating RIPK2-mediated signaling pathways, innate immune responses, and inflammatory disease mechanisms in both in vitro and in vivo experimental systems.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,4308-10 weeks8-10 weeks
50 mg$1,8608-10 weeks8-10 weeks
100 mg$2,8208-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
RIPK-IN-4 is a highly effective and selective small-molecule inhibitor of receptor-interacting protein kinase 2 (RIPK2) that demonstrates potent biochemical activity with an IC50 value of 3 nM, and it is further distinguished by excellent oral bioavailability, making it a valuable research tool for investigating RIPK2-mediated signaling pathways, innate immune responses, and inflammatory disease mechanisms in both in vitro and in vivo experimental systems.
Targets&IC50
RIPK2:3 nM
In vitro
Method: Liver microsomal stability assays were conducted using mouse, rat, and human liver microsomes.
Result: RIPK-IN-4 exhibited liver microsomal extraction ratios of 0.59 in mice, 0.45 in rats, and 0.39 in humans[1].
Chemical Properties
Molecular Weight392.45
FormulaC18H21FN4O3S
Cas No.2141969-56-2
SmilesO=S(=O)(C1=CN2C(=NC=C2C=3C=C(F)N=C(N)C3)C=C1OCC)C(C)(C)C
Relative Density.1.37 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 24 mg/mL (61.15 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5481 mL12.7405 mL25.4810 mL127.4048 mL
5 mM0.5096 mL2.5481 mL5.0962 mL25.4810 mL
10 mM0.2548 mL1.2740 mL2.5481 mL12.7405 mL
20 mM0.1274 mL0.6370 mL1.2740 mL6.3702 mL
50 mM0.0510 mL0.2548 mL0.5096 mL2.5481 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RIPK-IN-4RIPKIN4RIPK2RIPK IN 4
Related Tags: buy RIPK-IN-4 | purchase RIPK-IN-4 | RIPK-IN-4 cost | order RIPK-IN-4 | RIPK-IN-4 chemical structure | RIPK-IN-4 in vitro | RIPK-IN-4 formula | RIPK-IN-4 molecular weight
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