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DADPS Biotin Azide

Name: DADPS Biotin Azide
Brand: TargetMol
SKU: T17582
Price: 95 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Biotin-PEG4-amino-t-Bu-DADPS-C6-azide) Copy Product Info

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Synonyms: Biotin-PEG4-amino-t-Bu-DADPS-C6-azide

Catalog No. T17582 Copy Product Info

Purity: 97.18%

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DADPS Biotin Azide (Biotin-PEG4-amino-t-Bu-DADPS-C6-azide) is a PROTAC linker and a chemical linking unit used for constructing proteolysis-targeting chimeras, featuring favorable chemical cleavability and bioorthogonal reactivity, commonly employed in the synthesis of PROTAC molecules with targeted protein degradation functionality.

Cas No. 1260247-50-4

Pack Size	Price	USA Stock	Global Stock
1 mg	$95	In Stock	In Stock
5 mg	$235	In Stock	In Stock
10 mg	$372	In Stock	In Stock
25 mg	$613	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.18%

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	DADPS Biotin Azide (Biotin-PEG4-amino-t-Bu-DADPS-C6-azide) is a PROTAC linker and a chemical linking unit used for constructing proteolysis-targeting chimeras, featuring favorable chemical cleavability and bioorthogonal reactivity, commonly employed in the synthesis of PROTAC molecules with targeted protein degradation functionality.
In vitro	Methods: Synthetic O-GlcNAc peptides (containing Ser/Thr/Tyr modifications) were labeled with GalT1(Y289L) enzyme, followed by copper-catalyzed click reaction with DADPS-biotin-propargylamide (10 mM) for 2 hours; after enrichment, samples were cleaved with 10% FA for 1 hour and analyzed by nanoUPLC-MS/MS. Results: The DADPS probe successfully enriched all types of O-GlcNAc peptides with higher intensity than the Dde probe, suitable for O-GlcNAc proteomic analysis of complex samples. [1]
Synonyms	Biotin-PEG4-amino-t-Bu-DADPS-C6-azide

Chemical Properties

Molecular Weight	886.18
Formula	C₄₃H₆₇N₇O₉SSi
Cas No.	1260247-50-4
Smiles	[Si](OC(CNC(CCOCCOCCOCCOCCNC(CCCC[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H])=O)=O)(C)C)(OCCCCCCN=[N+]=[N-])(C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.	no data available

Storage & Solubility Information

Storage

Store at low temperature,The compound is unstable in solution. Please use soon Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 257.5 mg/mL (290.57 mM), Sonication is recommended. (The compound is unstable in solution, please use soon.)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (5.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1284 mL	5.6422 mL	11.2844 mL	56.4219 mL
5 mM	0.2257 mL	1.1284 mL	2.2569 mL	11.2844 mL
10 mM	0.1128 mL	0.5642 mL	1.1284 mL	5.6422 mL
20 mM	0.0564 mL	0.2821 mL	0.5642 mL	2.8211 mL
50 mM	0.0226 mL	0.1128 mL	0.2257 mL	1.1284 mL
100 mM	0.0113 mL	0.0564 mL	0.1128 mL	0.5642 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.