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DADPS Biotin Azide

Name: DADPS Biotin Azide
Brand: TargetMol
SKU: T17582
Price: 95 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17582Cas No. 1260247-50-4

Alias Biotin-PEG4-amino-t-Bu-DADPS-C6-azide

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEGylated PROTAC linker suitable for PROTAC synthesis [1].

DADPS Biotin Azide

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Purity: 97.18%

Catalog No. T17582Alias Biotin-PEG4-amino-t-Bu-DADPS-C6-azideCas No. 1260247-50-4

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEGylated PROTAC linker suitable for PROTAC synthesis [1].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$95	-	In Stock
5 mg	$235	In Stock	In Stock
10 mg	$372	-	In Stock
25 mg	$613	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:97.18%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEGylated PROTAC linker suitable for PROTAC synthesis [1].
In vitro	PROTACs, comprising two distinct ligands linked by a connector—one binding to an E3 ubiquitin ligase and the other to the target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Synonyms	Biotin-PEG4-amino-t-Bu-DADPS-C6-azide

Chemical Properties

Molecular Weight	886.18
Formula	C₄₃H₆₇N₇O₉SSi
Cas No.	1260247-50-4
Smiles	[Si](OC(CNC(CCOCCOCCOCCOCCNC(CCCC[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H])=O)=O)(C)C)(OCCCCCCN=[N+]=[N-])(C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.	no data available
Color	Yellow
Appearance	Oil

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 257.5 mg/mL (290.57 mM), Sonication is recommended. (The compound is unstable in solution, please use soon.)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (5.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1284 mL	5.6422 mL	11.2844 mL	56.4219 mL
5 mM	0.2257 mL	1.1284 mL	2.2569 mL	11.2844 mL
10 mM	0.1128 mL	0.5642 mL	1.1284 mL	5.6422 mL
20 mM	0.0564 mL	0.2821 mL	0.5642 mL	2.8211 mL
50 mM	0.0226 mL	0.1128 mL	0.2257 mL	1.1284 mL
100 mM	0.0113 mL	0.0564 mL	0.1128 mL	0.5642 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc