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Anti-CNDP1 Antibody (4Z744)
😃Good
Catalog No. TMAY-00226
Alias Cn1, carnosine dipeptidase 1 (metallopeptidase M20 family), AI746433
Anti-CNDP1 Antibody (4Z744) is a Mouse antibody targeting CNDP1. Anti-CNDP1 Antibody (4Z744) can be used in ELISA.
Anti-CNDP1 Antibody (4Z744)
Anti-CNDP1 Antibody (4Z744)
😃Good
Catalog No. TMAY-00226Alias Cn1, carnosine dipeptidase 1 (metallopeptidase M20 family), AI746433
Anti-CNDP1 Antibody (4Z744) is a Mouse antibody targeting CNDP1. Anti-CNDP1 Antibody (4Z744) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA Reactivity: Human |
| Alias | Cn1, carnosine dipeptidase 1 (metallopeptidase M20 family), AI746433 |
| Ig Type | Mouse IgG1 |
| Clone | 4Z744 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Carnosine Dipeptidase 1 (rhCNDP1; TMPY-00719; Ser27-His507; NP_116038.4). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | CNDP1, also known as carnosine dipeptidase 1, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. The CNDP1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region, which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy, for carnosine protection against the adverse effects of high glucose levels on renal cells. In humans, CNDP1 is secreted from the liver into the serum. In other mammals, including rodents, CNDP1 is expressed exclusively within the kidney and lacks a signal peptide. CNDP1 protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine (β-alanyl-L-histidine), and is identified as human carnosinase expressed in the brain. CNDP1 has been associated with diabetic nephropathy in Europeans and European Americans, but not African-Americans. It was identified and confirmed as a risk factor, were cross-sectional and mostly in patients with type 2 diabetes. The polymorphisms of CNDP1 can be excluded as a risk factor for nephropathy in type 1 diabetes. In addition, CNDP1 is also suggested to be implicated in the actions of neuroprotection and neurotransmiting. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CNDP1 Protein (TMPY-00719) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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