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DDR1-IN-6

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Catalog No. T40061Cas No. 2416021-47-9
Alias DDR1-IN-6

DDR1-IN-6 is a potent and selective inhibitor of Discoidin Domain Receptor family member 1 (DDR1), exhibiting remarkable inhibitory activity at an IC50 of 9.72 nM. It effectively suppresses the auto-phosphorylation of DDR1b (Y513) with an IC50 value of 9.7 nM. Furthermore, DDR1-IN-6 displays strong anti-cancer activity.

DDR1-IN-6

DDR1-IN-6

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Catalog No. T40061Alias DDR1-IN-6Cas No. 2416021-47-9
DDR1-IN-6 is a potent and selective inhibitor of Discoidin Domain Receptor family member 1 (DDR1), exhibiting remarkable inhibitory activity at an IC50 of 9.72 nM. It effectively suppresses the auto-phosphorylation of DDR1b (Y513) with an IC50 value of 9.7 nM. Furthermore, DDR1-IN-6 displays strong anti-cancer activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$1195 days5 days
5 mg$1977-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
DDR1-IN-6 is a potent and selective inhibitor of Discoidin Domain Receptor family member 1 (DDR1), exhibiting remarkable inhibitory activity at an IC50 of 9.72 nM. It effectively suppresses the auto-phosphorylation of DDR1b (Y513) with an IC50 value of 9.7 nM. Furthermore, DDR1-IN-6 displays strong anti-cancer activity.
Targets&IC50
DDR1:9.72 nM (IC50)
In vitro
DDR1-IN-6 (compound 1), when applied for 24 hours, effectively inhibits collagen production in the human hepatic stellate cell line LX-2, with an IC50 value of 13 nM. Additionally, after 72 hours of exposure, DDR1-IN-6 exhibits cytotoxic effects on LX-2 cells, with a CC50 value of 3 μM. Furthermore, DDR1-IN-6 demonstrates anti-proliferative activity against primary tumor cells freshly isolated from PC-07-0024, achieving IC50 values of 5.7 μM after 3 days and 2.65 μM after 6 days. However, in a LU-01-0523 derived xenograft (PDX) tumor model, DDR1-IN-6 shows limited efficacy, with IC50 values exceeding 30 μM for both 3 and 6 days of treatment.
SynonymsDDR1-IN-6
Chemical Properties
Molecular Weight433.394
FormulaC23H14F3N5O
Cas No.2416021-47-9
SmilesCc1ccc2c(Nc3cccc(c3)C(F)(F)F)noc2c1C#Cc1cnc2cccnn12
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

DDR-1-IN-6DDR1IN6DDR1 IN 6
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