Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Simotinib hydrochloride is a selective and orally bioavailable EGFR tyrosine kinase inhibitor, showing strong specificity with an IC 50 of 19.9 nM. This compound exhibits potent antineoplastic activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 970.00 |
Description | Simotinib hydrochloride is a selective and orally bioavailable EGFR tyrosine kinase inhibitor, showing strong specificity with an IC 50 of 19.9 nM. This compound exhibits potent antineoplastic activities. |
Targets&IC50 | EGFR:19.9 nM (pIC50) |
In vitro | Simotinib hydrochloride effectively inhibits EGFR and suppresses the growth of human A431 tumor cells, which highly express EGFR, in a dose-dependent manner. It demonstrates no significant activity against other kinases studied[1]. |
In vivo | Simotinib hydrochloride demonstrates antitumor efficacy through the inhibition of EGFR phosphorylation within a nude xenograft model[1]. |
Molecular Weight | 537.41 |
Formula | C25H27Cl2FN4O4 |
CAS No. | 1538617-88-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Simotinib hydrochloride 1538617-88-7 Simotinib Hydrochloride inhibitor inhibit