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m-3M3FBS

🥰Excellent
Catalog No. T8531Cas No. 200933-14-8

m-3M3FBS is a phospholipase C (PLC) activator.

m-3M3FBS

m-3M3FBS

🥰Excellent
Purity: 99.66%
Catalog No. T8531Cas No. 200933-14-8
m-3M3FBS is a phospholipase C (PLC) activator.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$43In StockIn Stock
10 mg$68In StockIn Stock
25 mg$133In StockIn Stock
50 mg$247In StockIn Stock
100 mg$409In StockIn Stock
1 mL x 10 mM (in DMSO)$48In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.66%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
m-3M3FBS is a phospholipase C (PLC) activator.
In vitro
m-3M3FBS stimulated a transient intracellular calcium concentration ([Ca(2+)](i)) increase in neutrophils.?Moreover, m-3M3FBS stimulated the formation of inositol phosphates in U937 cells, indicating that it stimulates PLC activity.?The compound showed no cell-type specificity in terms of [Ca(2+)](i) increase in the various cell lines including leukocytes, fibroblasts, and neuronal cells,?also ruled out the possible involvement of heterotrimeric G proteins in m-3M3FBS-stimulated signaling by confirming the following: 1) pertussis toxin does not inhibit m-3M3FBS-induced [Ca(2+)](i) increase;?2) m-3M3FBS does not stimulate cyclic AMP generation;?and 3) the inhibition of G(q) by the regulator of G protein-signaling 2 does not affect the m-3M3FBS-induced [Ca(2+)](i) increase.?m-3M3FBS stimulated PLC activity in vitro.?The purified isoforms of PLC that were tested (i.e., beta2, beta3, gamma1, gamma2, and delta1) were activated by m-3M3FBS and showed no isoform specificity[1].
Chemical Properties
Molecular Weight343.36
FormulaC16H16F3NO2S
Cas No.200933-14-8
SmilesCc1cc(C)c(c(C)c1)S(=O)(=O)Nc1cccc(c1)C(F)(F)F
Relative Density.1.316g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 4.4 mg/mL (12.81 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9124 mL14.5620 mL29.1240 mL145.6198 mL
5 mM0.5825 mL2.9124 mL5.8248 mL29.1240 mL
10 mM0.2912 mL1.4562 mL2.9124 mL14.5620 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

U937THP-1superoxidePLCPhospholipasephosphateneutrophilsm-3M-3FBSm-3M3FBSm3M3FBSm 3M3FBSleukemicinositolInhibitorinhibitcellscalciumApoptosis
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