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CID1231538

Name: CID1231538
Brand: TargetMol
SKU: T9162
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9162Cas No. 354126-20-8

CID1231538 is a potent GPR35 antagonist.

CID1231538

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Purity: 98.79%

Catalog No. T9162Cas No. 354126-20-8

CID1231538 is a potent GPR35 antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$83	In Stock	In Stock
10 mg	$133	In Stock	In Stock
25 mg	$268	In Stock	In Stock
50 mg	$395	In Stock	In Stock
100 mg	$563	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$95	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.79%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

CID1231538 AI Summary

CID1231538 exhibits a range of bioactivities, including inhibition of Lamin A splicing, ERK1/2 activity in GPR35-overexpressing cells, tau fibril formation, and aldehyde dehydrogenase 1 (ALDH1A1). It also targets HPGD, neuropeptide S receptor, human alpha-Glucosidase (both as an inhibitor and activator), Nrf2, and acts as a GPR35 antagonist. Further bioactivities include involvement in ELG1-dependent DNA repair, beta-2AR agonism, influencing Marburg and Lassa Virus entry, induction of DNA re-replication, ClpP activation, inhibition of secretory acid sphingomyelinase, Hepatitis C Virus, ATXN expression, GLP-1 receptor inverse agonism, and human tyrosyl-DNA phosphodiesterase 1 (TDP1) both in the absence and presence of CPT. It serves as a gsp antagonist and shows antiviral activity against Foot and Mouth Disease Virus. Notably, CID1231538 exhibits antagonist activity at the human N-terminal HA-tagged GPR35a expressed in human U2OS cells, inhibiting agonist-induced redistribution of GFP-fused beta arrestin-2 with an EC50 of 550.0 nM and zaprinast-induced effects with an IC50 of 4560.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CID1231538 is a potent GPR35 antagonist.
Targets&IC50	GPR35:0.55 μM

Chemical Properties

Molecular Weight	524.05
Formula	C₂₆H₂₂ClN₃O₃S₂
Cas No.	354126-20-8
Smiles	Clc1ccc(CSc2nc3ccc(NC(=O)c4ccccc4C(=O)N4CCOCC4)cc3s2)cc1
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (104.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9082 mL	9.5411 mL	19.0821 mL	95.4107 mL
5 mM	0.3816 mL	1.9082 mL	3.8164 mL	19.0821 mL
10 mM	0.1908 mL	0.9541 mL	1.9082 mL	9.5411 mL
20 mM	0.0954 mL	0.4771 mL	0.9541 mL	4.7705 mL
50 mM	0.0382 mL	0.1908 mL	0.3816 mL	1.9082 mL
100 mM	0.0191 mL	0.0954 mL	0.1908 mL	0.9541 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc