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Go6976

Name: Go6976
Brand: TargetMol
SKU: T6515
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6515Cas No. 136194-77-9

Alias Gö 6976

Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.

Go6976

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Purity: 95.89%

Catalog No. T6515Alias Gö 6976Cas No. 136194-77-9

Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$172	In Stock
10 mg	$277	In Stock
25 mg	$469	In Stock
50 mg	$673	In Stock
100 mg	$939	In Stock
1 mL x 10 mM (in DMSO)	$188	In Stock

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Purity:95.89%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.
Targets&IC50	PKCβ1:6.2 nM, PKC:20 nM, PKCα:2.3 nM, PKC:7.9 nM
In vitro	30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G2 arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G2 arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum[1]. Go6976 is a potent inhibitor of PKC in vitro (IC50 is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor[2]
Synonyms	Gö 6976

Chemical Properties

Molecular Weight	378.43
Formula	C₂₄H₁₈N₄O
Cas No.	136194-77-9
Smiles	Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45.0 mg/mL (118.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6425 mL	13.2125 mL	26.4250 mL	132.1248 mL
5 mM	0.5285 mL	2.6425 mL	5.2850 mL	26.4250 mL
10 mM	0.2642 mL	1.3212 mL	2.6425 mL	13.2125 mL
20 mM	0.1321 mL	0.6606 mL	1.3212 mL	6.6062 mL
50 mM	0.0528 mL	0.2642 mL	0.5285 mL	2.6425 mL
100 mM	0.0264 mL	0.1321 mL	0.2642 mL	1.3212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc