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Synonyms: USP 11, UHX1, UBP11_HUMAN, Ubiquitin-specific-processing protease 11, Ubiquitin thiolesterase 11, Ubiquitin specific protease 11, ubiquitin specific peptidase 11, Ubiquitin carboxyl-terminal hydrolase X linked, Ubiquitin carboxyl-terminal hydrolase 11, Deubiquitinating enzyme 11
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $298 | 7-10 days | 7-10 days | |
| 100 μL | $498 | 7-10 days | 7-10 days |
| Description | Anti-USP11 Antibody (1W222) is a Rabbit antibody targeting USP11. Anti-USP11 Antibody (1W222) can be used in FCM,ICC/IF,IP,WB. |
| Synonyms | USP 11, UHX1, UBP11_HUMAN, Ubiquitin-specific-processing protease 11, Ubiquitin thiolesterase 11, Ubiquitin specific protease 11, ubiquitin specific peptidase 11, Ubiquitin carboxyl-terminal hydrolase X linked, Ubiquitin carboxyl-terminal hydrolase 11, Deubiquitinating enzyme 11 |
| Ig Type | IgG |
| Clone | 1W222 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-1000; ICC/IF: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP11 (ubiquitin specific peptidase 11), also known as UHX1, is a 920 amino acid deubiquitinating enzyme that participates in the Ub pathway. Localized to the nucleus, USP11 associates with both Ran BP-M (Ran binding protein M) and with the tumor suppressor BRCA2. Through these associations, USP11 functions to either inhibit ubiquitination of these proteins or to remove ubiquitin residues that have already been attached to these proteins. USP11 is implicated in several X-linked retinal diseases and, due to its ability to deubiquitinate BRCA2, may play a role in tumor suppression. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 110 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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