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Hirudin (Synonyms: Hirudin (54-65; non-sulfated))

Name: Hirudin
Brand: TargetMol
SKU: T126366
Price: 153 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T126366 Copy Product Info

Purity: 99.75%

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Hirudin is a thrombin inhibitor that improves Gsdmd-mediated pyroptosis by inhibiting irf2. It can be used in research on diabetic nephropathy.

Hirudin

Copy Product Info

🥰Excellent

Catalog No. T126366

Synonyms Hirudin (54-65; non-sulfated)

Hirudin is a thrombin inhibitor that improves Gsdmd-mediated pyroptosis by inhibiting irf2. It can be used in research on diabetic nephropathy.

Cas No. 113274-56-9

Pack Size	Price	USA Stock	Global Stock
1 mg	$153	In Stock	In Stock
5 mg	$385	In Stock	In Stock
10 mg	$561	In Stock	In Stock
25 mg	$875	In Stock	In Stock
50 mg	$1,160	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.75%

Appearance:Solid

Color:White

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COA HPLC MS

Product Introduction

Bioactivity

Description	Hirudin is a thrombin inhibitor that improves Gsdmd-mediated pyroptosis by inhibiting irf2. It can be used in research on diabetic nephropathy.
In vitro	Hirudin prevents fibrin formation by inhibiting thrombin activity and impairing its ability to cleave fibrinogen, and inhibits the process of cross-linking and polymerization of fibrin monomers in the internal and external coagulation pathways. [1] High doses of Hirudin reduce the proliferation of human microvascular endothelial cells by inhibiting the VEGF-Notch pathway. [1] Hirudin (3-10 mg/mL) reverses TGF-β1-induced aberrant proliferation and fibrosis of HK-2 cells.[1] Hirudin is also effective in reducing the proliferation of human microvascular endothelial cells. [1] Hirudin inhibits angiotensin II-induced cardiac fibroblast activity in a dose-dependent manner, attenuates oxidative stress, modulates factors associated with fibrosis, and inhibits the ERK1/2 signaling pathway. [1]
In vivo	Hirudin improves the survival of randomized skin flaps in rats while significantly reducing the inflammatory response.Hirudin contributes to wound healing in SD rats after laser surgery. [1] In a mouse model of unilateral ureteral obstruction (UUO), Hirudin (10 and 15 mg/kg; gavage once daily for 21 days) reduced tubular injury and inflammation by ameliorating interstitial fibrosis. [2]
Synonyms	Hirudin (54-65; non-sulfated)

Chemical Properties

Molecular Weight	1468.52
Formula	C₆₆H₉₃N₁₃O₂₅
Cas No.	113274-56-9
Smiles	C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(CN)=O)CC(O)=O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)[C@H](CC)C)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)CC(C)C)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC2
Sequence	Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-Gln-NH2
Sequence Short	GDFEEIPEEYLQ-NH2

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (68.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6810 mL	3.4048 mL	6.8096 mL	34.0479 mL
5 mM	0.1362 mL	0.6810 mL	1.3619 mL	6.8096 mL
10 mM	0.0681 mL	0.3405 mL	0.6810 mL	3.4048 mL
20 mM	0.0340 mL	0.1702 mL	0.3405 mL	1.7024 mL
50 mM	0.0136 mL	0.0681 mL	0.1362 mL	0.6810 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc