Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NOS-IN-2 (Compound 4i), an imidamide-derived NOS inhibitor, exhibits high potency and selectivity, specifically inhibiting iNOS with an IC50 of 20 μM while sparing eNOS. Demonstrating minimal toxicity, it is suitable for research on inflammatory disorders [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | NOS-IN-2 (Compound 4i), an imidamide-derived NOS inhibitor, exhibits high potency and selectivity, specifically inhibiting iNOS with an IC50 of 20 μM while sparing eNOS. Demonstrating minimal toxicity, it is suitable for research on inflammatory disorders [1]. |
In vitro | NOS-IN-2 (Compound 4i) shows high iNOS selectivity without eNOS inhibition activity [1]. NOS-IN-2 (0-100 μM, 30 min) has little toxicity [1]. Cell Viability Assay [1] Cell Line: HUVECs Concentration: 10, 20, 50, 100, 500 μM Incubation Time: 30 min Result: Had little toxicity, only at the concentration above 100 μM, the cell viability was significantly (approximately 20%) reduced. |
In vivo | NOS-IN-2 (Compound 4i) is predicted to show oral bioavailability [1]. |
Molecular Weight | 367.37 |
Formula | C18H20F3N3O2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.