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Dimethyl fumarate

Name: Dimethyl fumarate
Brand: TargetMol
SKU: T0492
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0492Cas No. 624-49-7

Alias DMF

Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis.

Dimethyl fumarate

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Purity: 99.88%

Catalog No. T0492Alias DMFCas No. 624-49-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$45	In Stock	In Stock

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

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COA GC HNMR

Product Introduction

Bioactivity

Description	Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis.
In vitro	METHODS: Primary cortical cultures or hippocampal HT22 cells were treated with Dimethyl fumarate (10 µM) and glutamate for 24 h. Cell viability was measured by Cell Titer Blue (CTB) assay. RESULTS: Pre-incubation with 10 µM MMF Dimethyl fumarate for 24 h protected primary cortex cultures and hippocampal HT22 cells from oxidized glutamate toxicity. [1] METHODS: Tumor cells CT26 were treated with Dimethyl fumarate (100 µM) for 3-24 h. LDH release was detected by LDH cytotoxicity assay kit. RESULTS: Dimethyl fumarate time-dependently increased LDH release, which reflected necrotic cell death. [2]
In vivo	METHODS: To study the effects on Friedreich's ataxia (FA), Dimethyl fumarate (110 mg/kg) was administered orally to a FXNKD mouse model of FA once daily for 18 weeks. RESULTS: Dimethyl fumarate rescued these enzyme activities in the brain of the FXNKD mouse model and rescued frataxin and cytochrome oxidase expression in the brain, cerebellum, and quadriceps muscle. [3]
Synonyms	DMF

Chemical Properties

Molecular Weight	144.13
Formula	C₆H₈O₄
Cas No.	624-49-7
Smiles	C(/C=C/C(OC)=O)(OC)=O
Relative Density.	1.37 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (277.53 mM), Sonication is recommended.

Ethanol: 7.2 mg/mL (49.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 1.5 mg/mL (10.41 mM), Solution.

5% DMSO+95% Saline: 0.29 mg/mL (2.01 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.9382 mL	34.6909 mL	69.3818 mL	346.9090 mL
5 mM	1.3876 mL	6.9382 mL	13.8764 mL	69.3818 mL
10 mM	0.6938 mL	3.4691 mL	6.9382 mL	34.6909 mL
20 mM	0.3469 mL	1.7345 mL	3.4691 mL	17.3455 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.1388 mL	0.6938 mL	1.3876 mL	6.9382 mL
100 mM	0.0694 mL	0.3469 mL	0.6938 mL	3.4691 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc