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Dimethyl fumarate
🥰Excellent
Catalog No. T0492Cas No. 624-49-7
Alias DMF
Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis.
Dimethyl fumarate
🥰Excellent
Purity: 100%
Catalog No. T0492Alias DMFCas No. 624-49-7
Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $45 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis. |
| In vitro | METHODS: Primary cortical cultures or hippocampal HT22 cells were treated with Dimethyl fumarate (10 µM) and glutamate for 24 h. Cell viability was measured by Cell Titer Blue (CTB) assay. RESULTS: Pre-incubation with 10 µM MMF Dimethyl fumarate for 24 h protected primary cortex cultures and hippocampal HT22 cells from oxidized glutamate toxicity. [1] METHODS: Tumor cells CT26 were treated with Dimethyl fumarate (100 µM) for 3-24 h. LDH release was detected by LDH cytotoxicity assay kit. RESULTS: Dimethyl fumarate time-dependently increased LDH release, which reflected necrotic cell death. [2] |
| In vivo | METHODS: To study the effects on Friedreich's ataxia (FA), Dimethyl fumarate (110 mg/kg) was administered orally to a FXNKD mouse model of FA once daily for 18 weeks. RESULTS: Dimethyl fumarate rescued these enzyme activities in the brain of the FXNKD mouse model and rescued frataxin and cytochrome oxidase expression in the brain, cerebellum, and quadriceps muscle. [3] |
| Alias | DMF |
| Molecular Weight | 144.13 |
| Formula | C6H8O4 |
| Cas No. | 624-49-7 |
| Smiles | COC(=O)\C=C\C(=O)OC |
| Relative Density. | 1.37 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 15 mg/mL (104.07 mM), Sonication is recommended.  Ethanol: 7.2 mg/mL (49.95 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Saline: 1.5 mg/mL (10.41 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. 5% DMSO+95% Saline: 0.29 mg/mL (2.01 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Sci Citations
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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