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(Rac)-Modipafant

(Rac)-Modipafant
(Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia/reperfusion (I/R) in the superior mesenteric artery (SMA) of the rat.
Catalog No. T28081Cas No. 122956-68-7
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Purity:98.09%
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(Rac)-Modipafant

Catalog No. T28081Cas No. 122956-68-7

(Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia/reperfusion (I/R) in the superior mesenteric artery (SMA) of the rat.
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Pack SizePriceAvailabilityQuantity
1 mg$219In Stock
5 mg$548In Stock
10 mg$792In Stock
25 mg$1,220In Stock
50 mg$2,380In Stock
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Product Introduction

Bioactivity
Description
(Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia/reperfusion (I/R) in the superior mesenteric artery (SMA) of the rat.
In vivo
In anesthetized guinea pigs, (Rac)-Modipafant(UK-74505) at 30 and 100 μg/kg intravenously inhibited the bronchoconstrictor response to aerosolized PAF without affecting blood pressure or heart rate; oral (Rac)-Modipafant(UK-74505) inhibited the increase in permeability of rat skin vessels to intradermal PAF with an ED50 of 280 +/- 5 μg/kg; and in conscious dogs, complete inhibition of PAF-induced whole blood aggregation occurred in vitro for at least 14 hours following an oral dose of (Rac)-Modipafant(UK-74505)(75 μg/kg).[2]
AliasUK 74505, UK74505, UK-74505, Modipafant racemate
Chemical Properties
Molecular Weight605.09
FormulaC34H29ClN6O3
Cas No.122956-68-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (66.11 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6526 mL8.2632 mL16.5265 mL82.6323 mL
5 mM0.3305 mL1.6526 mL3.3053 mL16.5265 mL
10 mM0.1653 mL0.8263 mL1.6526 mL8.2632 mL
20 mM0.0826 mL0.4132 mL0.8263 mL4.1316 mL
50 mM0.0331 mL0.1653 mL0.3305 mL1.6526 mL

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