Bromodiphenhydramine (Ambodryl) has antimicrobial activities which can be used in the cutaneous allergies research. Bromodiphenhydramine is an effective antihistamine that can inhibit a large number of Gram-negative and Gram-positive bacteria [1] [2] [3].

Bromodiphenhydramine, administered in single doses of 1.5 and 3 μg/g, effectively safeguards mice against infection from a virulent Salmonella typhimurium strain and substantially inhibits the proliferation of this pathogen in the liver, spleen, and blood of treated animals compared to untreated controls [2].