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FK 3311

Name: FK 3311
Brand: TargetMol
SKU: T7207
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7207Cas No. 116686-15-8

Alias FK-3311, COX-2 Inhibitor V

FK 3311 (COX-2 Inhibitor V) is an orally available, cell-permeable sulfonanilide that functions as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID).

FK 3311

🥰Excellent

Purity: 97.98%

Catalog No. T7207Alias FK-3311, COX-2 Inhibitor VCas No. 116686-15-8

FK 3311 (COX-2 Inhibitor V) is an orally available, cell-permeable sulfonanilide that functions as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$37	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$101	In Stock	In Stock
50 mg	$158	In Stock	In Stock
100 mg	$236	In Stock	In Stock
200 mg	$346	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.98%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	FK 3311 (COX-2 Inhibitor V) is an orally available, cell-permeable sulfonanilide that functions as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID).
In vivo	Survival rate was significantly better (p <0.05) and serum GOT levels 30 min after reperfusion were significantly lower (p <0.05) in the FK 3311(FK) high-dose group compared to the other two groups. Four hours after reperfusion, GPT levels and liver tissue flow were significantly (p <0.05) better in the FK high-dose group compared to the control. Both 30 min and 4 hr after reperfusion, serum TxB(2) levels were significantly lower in the FK high-dose group compared to the control (p <0.05)[1].
Animal Research	Inbred male Lewis rats weighing 200-260 g were used. The donor liver was perfused with cold University of Wisconsin (UW) solution and then stored in the same solution at 4 degrees C for 18 hr. After the preservation period, orthotopic liver transplantation was performed. Animals were divided into three groups: the control group; the FK low-dose group (1 mg/kg FK3311 i.v. 20 min before reperfusion); and the FK high-dose group (3 mg/kg FK3311. 20 min before reperfusion). Survival rate, serum GOT and GPT levels, liver tissue blood flow, and serum thromboxane B(2) (TxB(2)) levels were compared among groups[1].
Synonyms	FK-3311, COX-2 Inhibitor V

Chemical Properties

Molecular Weight	341.33
Formula	C₁₅H₁₃F₂NO₄S
Cas No.	116686-15-8
Smiles	CC(=O)c1ccc(NS(C)(=O)=O)c(Oc2ccc(F)cc2F)c1
Relative Density.	1.419g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (292.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9297 mL	14.6486 mL	29.2972 mL	146.4858 mL
5 mM	0.5859 mL	2.9297 mL	5.8594 mL	29.2972 mL
10 mM	0.2930 mL	1.4649 mL	2.9297 mL	14.6486 mL
20 mM	0.1465 mL	0.7324 mL	1.4649 mL	7.3243 mL
50 mM	0.0586 mL	0.2930 mL	0.5859 mL	2.9297 mL
100 mM	0.0293 mL	0.1465 mL	0.2930 mL	1.4649 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc