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Cannabidivarin

Name: Cannabidivarin
Brand: TargetMol
SKU: T8162
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8162Cas No. 24274-48-4

Alias GWP-42006, GWP42006, GWP 42006, Cannabidivarin

Cannabidivarin (GWP42006) is a potent inhibitor against gamma 2 subunit of GABAA receptors. it may serve as a novel drug with definite control over childhood absence epilepsy.

Cannabidivarin

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Purity: 98.51%

Catalog No. T8162Alias GWP-42006, GWP42006, GWP 42006, CannabidivarinCas No. 24274-48-4

Cannabidivarin (GWP42006) is a potent inhibitor against gamma 2 subunit of GABAA receptors. it may serve as a novel drug with definite control over childhood absence epilepsy.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
2 mg	$68	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$143	In Stock	In Stock
25 mg	$277	In Stock	In Stock
50 mg	$438	In Stock	In Stock
100 mg	$647	In Stock	-
1 mL x 10 mM (in DMSO)	$113	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.51%

Color:White

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Product Introduction

Cannabidivarin AI Summary

Cannabidivarin exhibits diverse pharmacological activities across multiple biological targets. It acts as an antagonist at human GPR55 by inhibiting LPI-induced beta-arrestin recruitment in HEK293 cells, showing 56.0% inhibition. The compound demonstrates cytotoxicity against various human cell lines, including SH-SY5Y, HepG2, PC3, MCF7, A549, OVCAR, HCT116, and Caco-2 cells, with IC50 values ranging from 10,100 nM to 64,000 nM. In enzymatic assays, 1564522 inhibits FAAH, MAGL, DAGLalpha, NAAA, and [14C]-AEA uptake with varying potencies, while showing Ki values of 14,710 nM and 574 nM for CB1 and CB2 receptor displacement, respectively. The compound also exhibits ion channel modulation, acting as an antagonist on rat TRPM8 and an agonist on rat TRPA1, with IC50 and EC50 values of 900 nM and 420 nM, respectively. Additionally, it positively modulates CB2 receptor agonist activity with an EC50 of 12.59 nM and affects intracellular cAMP levels. It shows mixed inhibition of CYP enzymes, including CYP1A1, CYP2B6, CYP2D6, and CYP2C19. Moreover, Cannabidivarin displays both agonist and antagonist activities at various TRPV channels, impacts cAMP levels and ERK1/2 phosphorylation through GPR6 and GPR55 interactions, and inhibits LDHB activity. It also demonstrates protective effects against LiCl-induced nausea in rats with a minimum effective dose of 0.2 g/kg. These pharmacological profiles suggest that Cannabidivarin has significant potential in modulating endocannabinoid system components, ion channels, GPCRs, and enzymatic pathways involved in lipid metabolism and cell viability..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cannabidivarin (GWP42006) is a potent inhibitor against gamma 2 subunit of GABAA receptors. it may serve as a novel drug with definite control over childhood absence epilepsy.
Synonyms	GWP-42006, GWP42006, GWP 42006, Cannabidivarin

Chemical Properties

Molecular Weight	286.41
Formula	C₁₉H₂₆O₂
Cas No.	24274-48-4
Smiles	OC1=C(C(O)=CC(CCC)=C1)[C@H]2[C@H](C(C)=C)CCC(C)=C2
Relative Density.	1.046 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (157.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4915 mL	17.4575 mL	34.9150 mL	174.5749 mL
5 mM	0.6983 mL	3.4915 mL	6.9830 mL	34.9150 mL
10 mM	0.3491 mL	1.7457 mL	3.4915 mL	17.4575 mL
20 mM	0.1746 mL	0.8729 mL	1.7457 mL	8.7287 mL
50 mM	0.0698 mL	0.3491 mL	0.6983 mL	3.4915 mL
100 mM	0.0349 mL	0.1746 mL	0.3491 mL	1.7457 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc