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VU0422288
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Catalog No. T29135Cas No. 1630936-95-6
Alias VU-0422288, VU 0422288, ML-396, ML396, ML 396
VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobilization assay.VU0422288 can be used to study Rett syndrome (RTT).
VU0422288
😃Good
Purity: 99.77%
Catalog No. T29135Alias VU-0422288, VU 0422288, ML-396, ML396, ML 396Cas No. 1630936-95-6
VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobilization assay.VU0422288 can be used to study Rett syndrome (RTT).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $73 | In Stock | In Stock | |
| 10 mg | $123 | In Stock | In Stock | |
| 25 mg | $247 | In Stock | In Stock | |
| 50 mg | $396 | In Stock | In Stock | |
| 100 mg | $645 | In Stock | In Stock | |
| 500 mg | $1,330 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.77%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobilization assay.VU0422288 can be used to study Rett syndrome (RTT). |
| Targets&IC50 | mGluR4:108 nM (EC50), mGluR7:146 nM (EC50), mGluR8:128 nM (EC50) |
| In vitro | In coronal slices containing the hippocampus, VU0422288 (1 μM; 5 minutes) enhances the reduction in slope of the field excitatory postsynaptic potentials (fEPSPs) induced by 30 μM LSP4-2022[1].However, when administered alone for 10 minutes at a concentration of 1 μM, VU0422288 does not alter the slope of fEPSP, indicating that under stimulation conditions, mGlu7 does not possess reinforcing activity in Mecp2-/y slices[1]. |
| In vivo | In Mecp2+/- mice, VU0422288 (30 mg/kg; intraperitoneal injection; once daily for 17 days) rescues synaptic plasticity deficits and learning-memory phenotypes, reduces the frequency of respiratory pause, while showing no effect in Mecp2+/+ animals[1]. A single dose of VU0422288 (10 mg/kg; intraperitoneal injection) in adult male Sprague-Dawley rats exhibits a plasma/brain partition coefficient of 1.67, predicting a free brain concentration of approximately 40 nM[1]. |
| Synonyms | VU-0422288, VU 0422288, ML-396, ML396, ML 396 |
| Molecular Weight | 360.19 |
| Formula | C17H11Cl2N3O2 |
| Cas No. | 1630936-95-6 |
| Smiles | Clc1ccc(Oc2ccc(NC(=O)c3ccccn3)cc2Cl)nc1 |
| Relative Density. | 1.445 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.61 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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