4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant

Name: 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPS-00157
Rating: 4.5 (1 reviews)

(Synonyms: TNFRSF9, T-cell antigen ILA, CD137 antigen, 4-1BB) Copy Product Info

Synonyms: TNFRSF9, T-cell antigen ILA, CD137 antigen, 4-1BB

Catalog No. TMPS-00157 Copy Product Info

4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant is expressed in E. coli. The accession number is Q07011.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$138	7-10 days	7-10 days
10 µg	$215	7-10 days	7-10 days
20 µg	$339	7-10 days	7-10 days
50 µg	$625	7-10 days	7-10 days
100 µg	$996	7-10 days	7-10 days
200 µg	$1,590	7-10 days	7-10 days
500 µg	$2,960	7-10 days	7-10 days
1 mg	$4,750	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Fully biologically active when compared to standard. The biological activity is determined by its inhibitory effect of IL-8 production using human peripheral blood mononuclear cells. About 90 % of inibition was seen using a concentration of 1.0 μg for both 4-1BB Ligand and 4-1BB Receptor.
Description	4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant is expressed in E. coli. The accession number is Q07011.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	Q07011
Construction	Glu18-Ser184
Protein Purity	> 97% as determined by SDS-PAGE; > 97% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in 10 mM PB, pH 8.0, 150 mM NaCl.
Reconstitution	It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
Synonyms	TNFRSF9, T-cell antigen ILA, CD137 antigen, 4-1BB
Research Background	4-1BB(CD137) is a member of the tumor necrosis factor (TNF) receptor family. Mature human 4-1BB consists of a 163 amino acid extracellular domain (ECD) with four TNFR cysteine‑rich repeats, a 27 aa transmembrane segment, and a 42 aa cytoplasmic domain; 4-1BB (CD137) is expressed as a disulfide-linked homodimer on various populations of activated T cell including CD4 + , CD8 + , memory CD8 + , NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. It binds with high affinity to the transmembrane 4-1BB Ligand/TNFSF9 which is expressed on antigen presenting cells and myeloid progenitor cells. This interaction co-stimulates the proliferation, activation, and/or survival of the 4-1BB expressing cell. It can also enhance the activation-induced cell death of repetitively stimulated T cells.

Chemical Properties

Molecular Weight

17.7 kDa (Predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.