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Rilmenidine hemifumarate

Name: Rilmenidine hemifumarate
Brand: TargetMol
SKU: T21911
Rating: 4.5 (1 reviews)

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Catalog No. T21911Cas No. 207572-68-7

Alias S-3341 hemifumarate, Rilmenidine (hemifumarate)

Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells.

Rilmenidine hemifumarate

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Purity: 98.14%

Catalog No. T21911Alias S-3341 hemifumarate, Rilmenidine (hemifumarate)Cas No. 207572-68-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$72	1-2 weeks	1-2 weeks
10 mg	$98	1-2 weeks	1-2 weeks
25 mg	$168	1-2 weeks	1-2 weeks
50 mg	$247	1-2 weeks	1-2 weeks
100 mg	$365	1-2 weeks	1-2 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.14%

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COA HPLC

Product Introduction

Bioactivity

Description	Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells.
In vitro	Rilmenidine offers antihypertensive efficacy comparable to diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors. Rilmenidine (25-100 μM; 24 hours) also inhibits K562 cell proliferation[3].
In vivo	In Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week), significant improvement in forelimb grip strength and all limbs grip strength is observed from 12 to 22 weeks of age. Rilmenidine also decreases levels of mutant huntingtin[2].
Synonyms	S-3341 hemifumarate, Rilmenidine (hemifumarate)

Chemical Properties

Molecular Weight	238.28
Formula	C₁₀H₁₆N₂O.1/2C₄H₄O₄
Cas No.	207572-68-7
Smiles	C1CC1C(C2CC2)NC3=NCCO3.C1CC1C(C2CC2)NC3=NCCO3.C(=CC(=O)O)C(=O)O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 30 mg/mL (125.9 mM), Sonication is recommended.

DMSO: 5 mg/mL (125.90 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1967 mL	20.9837 mL	41.9674 mL	209.8372 mL
5 mM	0.8393 mL	4.1967 mL	8.3935 mL	41.9674 mL
10 mM	0.4197 mL	2.0984 mL	4.1967 mL	20.9837 mL
20 mM	0.2098 mL	1.0492 mL	2.0984 mL	10.4919 mL
50 mM	0.0839 mL	0.4197 mL	0.8393 mL	4.1967 mL
100 mM	0.0420 mL	0.2098 mL	0.4197 mL	2.0984 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc