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Rilmenidine hemifumarate

Catalog No. T21911 CAS 207572-68-7

Synonyms: Rilmenidine (hemifumarate), S-3341 hemifumarate

Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells.

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Rilmenidine hemifumarate Chemical Structure

Rilmenidine hemifumarate, CAS 207572-68-7

Pack Size	Availability	Price/USD
5 mg	5 days	$ 72.00
10 mg	5 days	$ 98.00
25 mg	5 days	$ 168.00
50 mg	5 days	$ 247.00
100 mg	5 days	$ 365.00

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Purity: 99.54%

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Description	Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells.
In vitro	Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors. Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation[3].
In vivo	In Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week), significant improvement in forelimb grip strength and all limbs grip strength is observed from 12 to 22 weeks of age. Rilmenidine also decreases levels of mutant huntingtin[2].

Synonyms	Rilmenidine (hemifumarate), S-3341 hemifumarate
Molecular Weight	238.28
Formula	C12H18O3
CAS No.	207572-68-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 30 mg/mL (125.90 mM)

DMSO: 5 mg/mL (125.90 mM), Sonication is recommended.

References and Literature

1. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S. 2. Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153. 3. Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library

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Keywords

Rilmenidine hemifumarate 207572-68-7 Apoptosis Neuroscience Imidazoline Receptor Rilmenidine (hemifumarate) S-3341 hemifumarate Rilmenidine inhibitor inhibit

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