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Anti-Olig-2/Oligo2 Polyclonal Antibody
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Catalog No. TMAB-01286
Alias RACK17, PRKCBP2, OLIGO2, Olig2, bHLHe19, BHLHB1
Anti-Olig-2/Oligo2 Polyclonal Antibody is a Rabbit antibody targeting Olig-2/Oligo2. Anti-Olig-2/Oligo2 Polyclonal Antibody can be used in ICC/IF.
Anti-Olig-2/Oligo2 Polyclonal Antibody
Anti-Olig-2/Oligo2 Polyclonal Antibody
😃Good
Catalog No. TMAB-01286Alias RACK17, PRKCBP2, OLIGO2, Olig2, bHLHe19, BHLHB1
Anti-Olig-2/Oligo2 Polyclonal Antibody is a Rabbit antibody targeting Olig-2/Oligo2. Anti-Olig-2/Oligo2 Polyclonal Antibody can be used in ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $222 | 7-10 days | |
| 100 μL | $372 | 7-10 days | |
| 200 μL | $528 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Olig-2/Oligo2 Polyclonal Antibody is a Rabbit antibody targeting Olig-2/Oligo2. Anti-Olig-2/Oligo2 Polyclonal Antibody can be used in ICC/IF. |
| Synonyms | RACK17, PRKCBP2, OLIGO2, Olig2, bHLHe19, BHLHB1 |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Rabbit,Sheep) |
| Verified Activity | U87MG cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Antibody incubation with (OLIG2) polyclonal Antibody, Unconjugated (TMAB-01286) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue) was used to stain the cell nucleus. |
| Application | |
| Recommended Dose | ICC/IF: 1:100 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. |
| Tissue Specificity | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human OLIG2 |
| Antigen Species | Human |
| Gene Name | OLIG2 |
| Gene ID | |
| Protein Name | Oligodendrocyte transcription factor 2 |
| Uniprot ID | |
| Biology Area | Transcription Factors,Oligodendrocyte marker,Neurogenesis,Neuron Restricted Lineage |
| Function | Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. |
| Molecular Weight | Theoretical: 32 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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