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AC-4-130

Name: AC-4-130
Brand: TargetMol
SKU: T35429
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35429Cas No. 1834571-82-2

Alias AC4-130, AC-4130, AC4130

AC-4-130 is a direct STAT5 SH2 domain inhibitor that can disrupt STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription, inducing cell cycle arrest and apoptosis in leukemia cells, and can be used for the study of acute myeloid leukemia (AML).

AC-4-130

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Purity: 99.93%

Catalog No. T35429Alias AC4-130, AC-4130, AC4130Cas No. 1834571-82-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	-	In Stock
5 mg	$198	-	In Stock
10 mg	$313	-	In Stock
25 mg	$619	-	In Stock
50 mg	$997	-	In Stock
100 mg	$1,860	-	In Stock
1 mL x 10 mM (in DMSO)	$226	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AC-4-130 is a direct STAT5 SH2 domain inhibitor that can disrupt STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription, inducing cell cycle arrest and apoptosis in leukemia cells, and can be used for the study of acute myeloid leukemia (AML).
In vitro	AC-4-130 (0.1–100 μM; 72 hours) induces apoptosis in MV4-11 or MOLM-13 cells in a dose- and time-dependent manner[1]. AC-4-130 (2/5 μM; 72 hours) induced cell cycle arrest, with increased G0/G1-arrested cells and reduced S or G2/M phase cells [1]. AC-4-130 (0.5–2 μM; 24 hours) resulted in decreased pY-STAT5 levels in both cytoplasm and nucleus [1].
Synonyms	AC4-130, AC-4130, AC4130

Chemical Properties

Molecular Weight	751.2
Formula	C₃₇H₃₆ClF₅N₂O₅S
Cas No.	1834571-82-2
Smiles	O=C(O)C1=CC=C(C=C1)N(C(=O)CN(CC2=CC=C(Cl)C=C2)S(=O)(=O)C=3C(F)=C(F)C(F)=C(F)C3F)CC=4C=C(C=C(C4)C(C)(C)C)C(C)(C)C
Relative Density.	1.362 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 80 mg/mL (106.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3312 mL	6.6560 mL	13.3120 mL	66.5602 mL
5 mM	0.2662 mL	1.3312 mL	2.6624 mL	13.3120 mL
10 mM	0.1331 mL	0.6656 mL	1.3312 mL	6.6560 mL
20 mM	0.0666 mL	0.3328 mL	0.6656 mL	3.3280 mL
50 mM	0.0266 mL	0.1331 mL	0.2662 mL	1.3312 mL
100 mM	0.0133 mL	0.0666 mL	0.1331 mL	0.6656 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc