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Pirimiphos-methyl

Name: Pirimiphos-methyl
Brand: TargetMol
SKU: T20539
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20539Cas No. 29232-93-7

Alias R 33986, PP511, Caswell No. 334B, AI3-27699, Actelic

Pirimiphos-methyl (AI3-27699) is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, moths, snout beetles and Ephestia cautella during storage of agricultural grains.

Pirimiphos-methyl

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Purity: 98.29%

Catalog No. T20539Alias R 33986, PP511, Caswell No. 334B, AI3-27699, ActelicCas No. 29232-93-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.29%

Appearance:Viscous

Color:Yellow

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COA HNMR LCMS

Product Introduction

Pirimiphos-methyl AI Summary

Pirimiphos-methyl exhibits multi-faceted bioactivity, serving as an inhibitor of the vitamin D receptor (VDR) with a potency of 89125.1 nM and as a small molecule antagonist of retinoid X receptor alpha signaling with a potency of 25118.9 nM. It demonstrates robust insecticidal properties, effectively controlling various insect pests. Against female Bemisia tabaci biotypes Q and B on cucumber leaves, it has LC50 values of 235.1 ppm and 188.0 ppm, respectively, indicating slightly higher susceptibility in the Q biotype. It also shows acaricidal activity against adult Tetranychus urticae with varying potencies across different populations, reflecting diverse resistance levels. For stored grain pests, Pirimiphos-methyl induces mortality rates between 97.8% to 100.0% against species such as Liposcelis paeta, Liposcelis bostrychophila, Liposcelis entomophila, and Lepinotus reticulatus at 8 ppm concentration after 7 to 14 days of exposure. Additionally, it exhibits high insecticidal activity against OP-susceptible strains of rice stem borer Chilo suppressalis with an LD50 of 1.5 mg/kg and maintains efficacy in OP-resistant strains with an LC50 of 1202.0. Furthermore, it functions as an nAChR antagonist in Myzus persicae (green peach aphid) with a displacement activity of 2.0% at 1 ppm after 70 minutes. Overall, Pirimiphos-methyl is a potent bioactive agent with diverse applications in pest control and regulatory receptor inhibition..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pirimiphos-methyl (AI3-27699) is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, moths, snout beetles and Ephestia cautella during storage of agricultural grains.
Synonyms	R 33986, PP511, Caswell No. 334B, AI3-27699, Actelic

Chemical Properties

Molecular Weight	305.33
Formula	C₁₁H₂₀N₃O₃PS
Cas No.	29232-93-7
Smiles	O(P(OC)(OC)=S)C1=NC(N(CC)CC)=NC(C)=C1
Relative Density.	1.229g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (196.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2751 mL	16.3757 mL	32.7514 mL	163.7572 mL
5 mM	0.6550 mL	3.2751 mL	6.5503 mL	32.7514 mL
10 mM	0.3275 mL	1.6376 mL	3.2751 mL	16.3757 mL
20 mM	0.1638 mL	0.8188 mL	1.6376 mL	8.1879 mL
50 mM	0.0655 mL	0.3275 mL	0.6550 mL	3.2751 mL
100 mM	0.0328 mL	0.1638 mL	0.3275 mL	1.6376 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc