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PF 03716556

🥰Excellent
TargetMol
Catalog No. T2093Cas No. 928774-43-0
Alias PF-3716556

PF 03716556 (PF-3716556) , an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease.

PF 03716556
Other Forms of PF 03716556:
(S)-PF-03716556T2093L928774-44-1
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PF 03716556

🥰Excellent
TargetMol
Purity: 99.85%
Catalog No. T2093Alias PF-3716556Cas No. 928774-43-0
PF 03716556 (PF-3716556) , an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease.
Pack SizePriceAvailabilityQuantity
2 mg$35In Stock
5 mg$55In Stock
10 mg$88In Stock
25 mg$177In Stock
50 mg$337In Stock
100 mg$532In Stock
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Bulk & Custom
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.85%
ee:100%
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COA HNMR LCMS CSFC

Product Introduction

Bioactivity
Description
PF 03716556 (PF-3716556) , an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease.
Targets&IC50
H+, K+-ATPase:6.5(pIC50)
In vitro
PF 03716556 is highly selective for H+ (pIC50=6.026),K+-ATPase (pIC50=7.095).
In vivo
PF 03716556 is highly selective for H+ (pIC50=6.026),K+-ATPase (pIC50=7.095).
SynonymsPF-3716556
Chemical Properties
Molecular Weight394.47
FormulaC22H26N4O3
Cas No.928774-43-0
SmilesCN(CCO)C(=O)c1cc(N[C@@H]2CCOc3cccc(C)c23)c2nc(C)cn2c1
Relative Density.1.30 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 39.5 mg/mL (100.13 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5350 mL12.6752 mL25.3505 mL126.7524 mL
5 mM0.5070 mL2.5350 mL5.0701 mL25.3505 mL
10 mM0.2535 mL1.2675 mL2.5350 mL12.6752 mL
20 mM0.1268 mL0.6338 mL1.2675 mL6.3376 mL
50 mM0.0507 mL0.2535 mL0.5070 mL2.5350 mL
100 mM0.0254 mL0.1268 mL0.2535 mL1.2675 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Keywords

PF3716556PF-03716556PF03716556PF 3716556PF 03716556H+/K+-ATPase
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