PTPN12 Protein, Human, Recombinant

Name: PTPN12 Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPY-03548
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: PTP-PEST, PTPG1, protein tyrosine phosphatase, non-receptor type 12) Copy Product Info

Synonyms: PTP-PEST, PTPG1, protein tyrosine phosphatase, non-receptor type 12

Catalog No. TMPY-03548 Copy Product Info

PTPN12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 41.8 kDa and the accession number is AAA36529.1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$80	-	In Stock
10 µg	$128	-	In Stock
20 µg	$209	-	In Stock
50 µg	$416	-	In Stock
100 µg	$700	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:90.1%

Appearance:Liquid

Color:Transparent

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site . The specific activity is >20 µmol/min/mg.
Description	PTPN12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 41.8 kDa and the accession number is AAA36529.1.
Species	Human
Expression System	Baculovirus Insect Cells
Tag	Tag Free
Accession Number	AAA36529.1
Construction	A DNA sequence encoding the human PTPN12 (AAA36529.1) (Met1-Gln355) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus. Predicted N terminal: Gly
Protein Purity	> 85 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.0.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	PTP-PEST, PTPG1, protein tyrosine phosphatase, non-receptor type 12
Research Background	PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN12 contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. PTPN12 was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. PTPN12 was shown to interact with, and dephosphorylate, various cytoskeleton and cell adhesion molecules, such as p13 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.

Chemical Properties

Molecular Weight

41.8 kDa (predicted); 41 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.