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Anti-SDF-1/CXCL12 Polyclonal Antibody

😃Good
Catalog No. TMAB-01671
Alias TPAR1, TLSF, SDF-1, SDF1, SCYB12, PBSF, IRH, chemokine (C-X-C motif) ligand 12

Anti-SDF-1/CXCL12 Polyclonal Antibody is a Rabbit antibody targeting SDF-1/CXCL12. Anti-SDF-1/CXCL12 Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P,WB.

Anti-SDF-1/CXCL12 Polyclonal Antibody

Anti-SDF-1/CXCL12 Polyclonal Antibody

😃Good
Catalog No. TMAB-01671Alias TPAR1, TLSF, SDF-1, SDF1, SCYB12, PBSF, IRH, chemokine (C-X-C motif) ligand 12
Anti-SDF-1/CXCL12 Polyclonal Antibody is a Rabbit antibody targeting SDF-1/CXCL12. Anti-SDF-1/CXCL12 Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P,WB.
Pack SizePriceAvailabilityQuantity
50 μL$2207-10 days
100 μL$3737-10 days
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Product Introduction

Bioactivity
Description
Anti-SDF-1/CXCL12 Polyclonal Antibody is a Rabbit antibody targeting SDF-1/CXCL12. Anti-SDF-1/CXCL12 Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P,WB.
SynonymsTPAR1, TLSF, SDF-1, SDF1, SCYB12, PBSF, IRH, chemokine (C-X-C motif) ligand 12
Ig Type
IgG
Reactivity
Human,Mouse (predicted:Rat,Chicken,Dog,Pig,GuineaPig,Rabbit)
Verified Activity
Sample:
Lane 1: Mouse Liver tissue lysates
Lane 2: Human HT-1080 tissue lysates
Lane3: Human A549 cell lysates
Lane4: Human HeLa cell lysates
Lane 5: Human MCF-7 cell lysates
Lane 6: Human HepG2 cell lysates
Primary: Anti-CXCL12 (TMAB-01671) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 8 kDa
Observed band size: 10 kDa
Application
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:50-200; ELISA: 1:5000-10000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted.
Tissue SpecificityIsoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and i
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundThis gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013].
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human SDF-1/CXCL12
Antigen Species
Human
Gene Name
CXCL12
Gene ID
Protein Name
Stromal cell-derived factor 1
Uniprot ID
Biology Area
Chemokines,Alpha Chemokines (CXC),Host Virus Interaction
Function
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to another C-X-C chemokine receptor CXCR7, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and CXCR7, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of CXCR7 expressed in various cells.
Chemical Properties
Molecular WeightTheoretical: 8 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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