Shopping Cart
- Remove All
- Your shopping cart is currently empty
Anti-SDF-1/CXCL12 Polyclonal Antibody is a Rabbit antibody targeting SDF-1/CXCL12. Anti-SDF-1/CXCL12 Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P,WB.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $220 | 7-10 days | |
100 μL | $373 | 7-10 days |
Description | Anti-SDF-1/CXCL12 Polyclonal Antibody is a Rabbit antibody targeting SDF-1/CXCL12. Anti-SDF-1/CXCL12 Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P,WB. |
Synonyms | TPAR1, TLSF, SDF-1, SDF1, SCYB12, PBSF, IRH, chemokine (C-X-C motif) ligand 12 |
Ig Type | IgG |
Reactivity | Human,Mouse (predicted:Rat,Chicken,Dog,Pig,GuineaPig,Rabbit) |
Verified Activity | Sample: Lane 1: Mouse Liver tissue lysates Lane 2: Human HT-1080 tissue lysates Lane3: Human A549 cell lysates Lane4: Human HeLa cell lysates Lane 5: Human MCF-7 cell lysates Lane 6: Human HepG2 cell lysates Primary: Anti-CXCL12 (TMAB-01671) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 8 kDa Observed band size: 10 kDa |
Application | |
Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:50-200; ELISA: 1:5000-10000 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Subcellular Localization | Secreted. |
Tissue Specificity | Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and i |
Construction | Polyclonal Antibody |
Purification | Protein A purified |
Appearance | Liquid |
Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Concentration | 1 mg/mL |
Research Background | This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]. |
Immunogen | KLH conjugated synthetic peptide: human SDF-1/CXCL12 |
Antigen Species | Human |
Gene Name | CXCL12 |
Gene ID | |
Protein Name | Stromal cell-derived factor 1 |
Uniprot ID | |
Biology Area | Chemokines,Alpha Chemokines (CXC),Host Virus Interaction |
Function | Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to another C-X-C chemokine receptor CXCR7, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and CXCR7, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of CXCR7 expressed in various cells. |
Molecular Weight | Theoretical: 8 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.