Shopping Cart

Remove All
Your shopping cart is currently empty

TH287

Name: TH287
Brand: TargetMol
SKU: T2069
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2069Cas No. 1609960-30-6

TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.

TH287

🥰Excellent

Purity: 99%

Catalog No. T2069Cas No. 1609960-30-6

TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.

Pack Size	Price	Availability
1 mg	$31	In Stock
2 mg	$41	In Stock
5 mg	$66	In Stock
10 mg	$97	In Stock
25 mg	$198	In Stock
50 mg	$386	In Stock
100 mg	$573	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99%

Resource Download

COA

Product Introduction

Bioactivity

Description	TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
Targets&IC50	MTH1:0.8 nM
In vitro	TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage. [1]
In vivo	In C57Bl/6 mice, TH287 (5 mk/kg, i.p.) causes a peak time and maximum concentration of 0.5 h and 0.82 μM. [2]

Chemical Properties

Molecular Weight	269.13
Formula	C₁₁H₁₀Cl₂N₄
Cas No.	1609960-30-6
Smiles	CNc1cc(nc(N)n1)-c1cccc(Cl)c1Cl
Relative Density.	1.440 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 10 mg/mL (37.15 mM), Heating is recommended.

DMSO: 49 mg/mL (182.07 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7157 mL	18.5784 mL	37.1568 mL	185.7838 mL
5 mM	0.7431 mL	3.7157 mL	7.4314 mL	37.1568 mL
10 mM	0.3716 mL	1.8578 mL	3.7157 mL	18.5784 mL
20 mM	0.1858 mL	0.9289 mL	1.8578 mL	9.2892 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0743 mL	0.3716 mL	0.7431 mL	3.7157 mL
100 mM	0.0372 mL	0.1858 mL	0.3716 mL	1.8578 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc