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Lobeglitazone Sulfate

Name: Lobeglitazone Sulfate
Brand: TargetMol
SKU: T27841
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27841Cas No. 763108-62-9

Alias Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang, CKD-501 Sulfate, CKD501 Sulfate, CKD-501, CKD501, CKD 501 Sulfate, CKD 501

Lobeglitazone Sulfate(CKD-501 Sulfate) is a novel thiazolidinedione with anti-inflammatory activity that inhibits LPS-induced NLRP3 inflammasome activation and hepatic inflammation, and can be used in the study of type 2 diabetes mellitus (T2DM).

Lobeglitazone Sulfate

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Purity: 99.6%

Catalog No. T27841Alias Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang, CKD-501 Sulfate, CKD501 Sulfate, CKD-501, CKD501, CKD 501 Sulfate, CKD 501Cas No. 763108-62-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	-	In Stock
5 mg	$167	-	In Stock
10 mg	$268	-	In Stock
25 mg	$427	-	In Stock
50 mg	$636	-	In Stock
100 mg	$930	-	In Stock
200 mg	$1,250	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.6%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Lobeglitazone Sulfate(CKD-501 Sulfate) is a novel thiazolidinedione with anti-inflammatory activity that inhibits LPS-induced NLRP3 inflammasome activation and hepatic inflammation, and can be used in the study of type 2 diabetes mellitus (T2DM).
Targets&IC50	PPARγ:137.4 nM (EC50), PPARα:546.3 nM (EC50)
Synonyms	Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang, CKD-501 Sulfate, CKD501 Sulfate, CKD-501, CKD501, CKD 501 Sulfate, CKD 501

Chemical Properties

Molecular Weight	578.61
Formula	C₂₄H₂₆N₄O₉S₂
Cas No.	763108-62-9
Smiles	O=C1SC(C(=O)N1)CC2=CC=C(OCCN(C=3N=CN=C(OC4=CC=C(OC)C=C4)C3)C)C=C2.O=S(=O)(O)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (86.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7283 mL	8.6414 mL	17.2828 mL	86.4140 mL
5 mM	0.3457 mL	1.7283 mL	3.4566 mL	17.2828 mL
10 mM	0.1728 mL	0.8641 mL	1.7283 mL	8.6414 mL
20 mM	0.0864 mL	0.4321 mL	0.8641 mL	4.3207 mL
50 mM	0.0346 mL	0.1728 mL	0.3457 mL	1.7283 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc