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K114

Name: K114
Brand: TargetMol
SKU: T19018
Rating: 4.5 (1 reviews)

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Catalog No. T19018Cas No. 872201-12-2

K114 binds tightly to amyloid fibrils (EC50: 20-30 nM). K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI).

K114

😃Good

Catalog No. T19018Cas No. 872201-12-2

K114 binds tightly to amyloid fibrils (EC50: 20-30 nM). K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$558	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	K114 binds tightly to amyloid fibrils (EC50: 20-30 nM). K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI).
In vitro	The unusually low buffer fluorescence of K114 is due to self-quenching in sedimentable aggregates or micelles which upon interacting with amyloid fibrils undergo an enhancement in fluorescence intensity and shifts in the excitation and emission spectra [1].

Chemical Properties

Molecular Weight	393.27
Formula	C₂₂H₁₇BrO₂
Cas No.	872201-12-2
Smiles	Oc1ccc(\C=C\c2ccc(\C=C\c3ccc(O)cc3)c(Br)c2)cc1
Relative Density.	1.462 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (254.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5428 mL	12.7139 mL	25.4278 mL	127.1391 mL
5 mM	0.5086 mL	2.5428 mL	5.0856 mL	25.4278 mL
10 mM	0.2543 mL	1.2714 mL	2.5428 mL	12.7139 mL
20 mM	0.1271 mL	0.6357 mL	1.2714 mL	6.3570 mL
50 mM	0.0509 mL	0.2543 mL	0.5086 mL	2.5428 mL
100 mM	0.0254 mL	0.1271 mL	0.2543 mL	1.2714 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

K-114K114K 114