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RS 8359

Name: RS 8359
Brand: TargetMol
SKU: T16803
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16803Cas No. 105365-76-2

RS 8359 is a reversible inhibitor of monoamine oxidase A (MAO-A) with a selectivity ratio of about 2200 for the A:B enzyme types. RS 8359 has antidepressant activity.

RS 8359

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Purity: 99.3%

Catalog No. T16803Cas No. 105365-76-2

RS 8359 is a reversible inhibitor of monoamine oxidase A (MAO-A) with a selectivity ratio of about 2200 for the A:B enzyme types. RS 8359 has antidepressant activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$74	In Stock	In Stock
5 mg	$179	In Stock	In Stock
10 mg	$289	In Stock	In Stock
25 mg	$579	In Stock	In Stock
50 mg	$932	In Stock	In Stock
100 mg	$1,490	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.3%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	RS 8359 is a reversible inhibitor of monoamine oxidase A (MAO-A) with a selectivity ratio of about 2200 for the A:B enzyme types. RS 8359 has antidepressant activity.
In vivo	RS 8359 demonstrates minimal impact on blood pressure when co-administered with tyramine, effectively mitigating the 'cheese' effect associated with traditional monoamine oxidase inhibitors, and exhibits low affinity for central nervous system receptors and minimal anticholinergic effects[1].

Chemical Properties

Molecular Weight	252.27
Formula	C₁₄H₁₂N₄O
Cas No.	105365-76-2
Smiles	OC1CCc2c1ncnc2Nc1ccc(cc1)C#N
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 48 mg/mL (190.27 mM), Sonication and heating to 80℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9640 mL	19.8200 mL	39.6401 mL	198.2003 mL
5 mM	0.7928 mL	3.9640 mL	7.9280 mL	39.6401 mL
10 mM	0.3964 mL	1.9820 mL	3.9640 mL	19.8200 mL
20 mM	0.1982 mL	0.9910 mL	1.9820 mL	9.9100 mL
50 mM	0.0793 mL	0.3964 mL	0.7928 mL	3.9640 mL
100 mM	0.0396 mL	0.1982 mL	0.3964 mL	1.9820 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc