dMCL1-2

Name: dMCL1-2
Brand: TargetMol
SKU: T13657
Rating: 4.5 (1 reviews)

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Catalog No. T13657Cas No. 2351218-88-5

dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.

dMCL1-2

😃Good

Catalog No. T13657Cas No. 2351218-88-5

dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$8,005	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly

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Product Introduction

Bioactivity

Description	dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.
Targets&IC50	MCL1:(kd)30 nM

Chemical Properties

Molecular Weight	1163.3
Formula	C₆₁H₆₆N₁₀O₁₂S
Cas No.	2351218-88-5
Smiles	O=C(O)C1=C(C=2C=CC=C(C=3C(=NN(C3COC4=CC=C(C=C4)N5CCN(CC5)S(=O)(=O)N(C)C)C)C)C2N1CCN6CCN(C(=O)COC7=CC=CC=8C(=O)N(C(=O)C78)C9C(=O)NC(=O)CC9)CC6)CCCOC%10=CC=CC=%11C=CC=CC%10%11
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

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