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Usmarapride

Name: Usmarapride
Brand: TargetMol
SKU: T63069
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SUVN-D-4010, SUVN-D4010, SUVN-D 4010) Copy Product Info

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Synonyms: SUVN-D-4010, SUVN-D4010, SUVN-D 4010

Catalog No. T63069 Copy Product Info

Purity: 99.59%

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Usmarapride is a potent and selective 5‑HT₄ receptor partial agonist (EC₅₀ = 27.5 nM) with oral bioavailability and blood–brain barrier penetrability, suitable for research on cognitive dysfunction associated with Alzheimer’s disease.

Cas No. 1428862-33-2

Pack Size	Price	USA Stock	Global Stock
1 mg	$118	-	In Stock
5 mg	$293	-	In Stock
10 mg	$469	-	In Stock
25 mg	$981	-	In Stock
50 mg	$1,570	-	In Stock
100 mg	$2,530	-	In Stock
1 mL x 10 mM (in DMSO)	$297	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.59%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Usmarapride is a potent and selective 5‑HT₄ receptor partial agonist (EC₅₀ = 27.5 nM) with oral bioavailability and blood–brain barrier penetrability, suitable for research on cognitive dysfunction associated with Alzheimer’s disease.
Targets & IC50	5-HT4 Receptor:44 nM (EC50)
In vivo	Methods: Male Wistar rats aged 10–12 weeks were orally administered usmarapride (1–3 mg/kg; p.o.). Results: Usmarapride ameliorated long-term memory impairment in the object recognition test (ORT). Methods: Rats were orally administered usmarapride (1, 3, 10 mg/kg; p.o.). Results: Usmarapride significantly reversed scopolamine-induced amnesia. Methods: The effects of usmarapride on parameters related to the object recognition test in rats were determined. Results: Usmarapride exerted statistically significant effects on both exploration time and recognition index at a dose of 3.0 mg/kg [1]. Methods: The pharmacokinetics and tissue distribution characteristics of usmarapride in rats were investigated. Results: Usmarapride exhibited favorable oral exposure, bioavailability and brain exposure in rats [1]. Methods: Rats were orally administered 3.0 mg/kg and intravenously administered 1.0 mg/kg usmarapride, respectively. Results: The pharmacokinetic study of usmarapride in rats was completed [1].
Synonyms	SUVN-D-4010, SUVN-D4010, SUVN-D 4010

Chemical Properties

Molecular Weight	473.53
Formula	C₂₃H₃₁N₅O₆
Cas No.	1428862-33-2
Smiles	O=C(O)C(=O)O.N=1N=C(OC1C2=NN(C=3C=CC=CC23)C(C)C)C4CCN(CCCOC)CC4

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 26.66 mg/mL (56.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1118 mL	10.5590 mL	21.1180 mL	105.5899 mL
5 mM	0.4224 mL	2.1118 mL	4.2236 mL	21.1180 mL
10 mM	0.2112 mL	1.0559 mL	2.1118 mL	10.5590 mL
20 mM	0.1056 mL	0.5279 mL	1.0559 mL	5.2795 mL
50 mM	0.0422 mL	0.2112 mL	0.4224 mL	2.1118 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.