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Mapracorat
🥰Excellent
Catalog No. T13451LCas No. 887375-26-0
Alias ZK-245186, ZK245186, BOL-303242X, BOL303242X
Mapracorat (ZK-245186, BOL-303242X) is a selective glucocorticoid receptor agonist commonly used as an anti-inflammatory agent for atopic dermatitis, post-cataract surgery inflammation, and allergic conjunctivitis.
Mapracorat
🥰Excellent
Catalog No. T13451LAlias ZK-245186, ZK245186, BOL-303242X, BOL303242XCas No. 887375-26-0
Mapracorat (ZK-245186, BOL-303242X) is a selective glucocorticoid receptor agonist commonly used as an anti-inflammatory agent for atopic dermatitis, post-cataract surgery inflammation, and allergic conjunctivitis.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Mapracorat (ZK-245186, BOL-303242X) is a selective glucocorticoid receptor agonist commonly used as an anti-inflammatory agent for atopic dermatitis, post-cataract surgery inflammation, and allergic conjunctivitis. |
| Targets&IC50 | TNFα secretion (canine PBMCs):0.2 nmol/L, TNFα secretion (murine BMDCs):0.5 nmol/L |
| In vitro | The in vitro activity of mapracorat was evaluated in canine peripheral blood mononuclear cells (PBMCs) and murine bone marrow–derived dendritic cells (BMDCs). Cells were pretreated with mapracorat (0.1–100 nmol/L) for 30 minutes, then stimulated with lipopolysaccharide (1 μg/mL) and incubated for 24 hours. TNFα levels in the supernatant were measured by ELISA. Mapracorat dose-dependently inhibited TNFα secretion, with IC₅₀ values of approximately 0.2 nmol/L (canine PBMCs) and 0.5 nmol/L (murine BMDCs) [1]. |
| In vivo | The in vivo activity of mapracorat was assessed in a canine skin inflammation model. Beagle dogs received topical applications of 0.1% mapracorat (500 μL in acetone) on shaved skin areas, once daily for four doses. One hour after the final application, compound 48/80 (50 μg/50 μL) was intradermally injected to induce wheal and erythema. Mapracorat significantly reduced both wheal and erythema size, comparable to 0.015% triamcinolone acetonide [1]. |
| Alias | ZK-245186, ZK245186, BOL-303242X, BOL303242X |
| Molecular Weight | 462.48 |
| Formula | C25H26F4N2O2 |
| Cas No. | 887375-26-0 |
| Smiles | C(C[C@@](CNC=1C2=C(C=CC1)N=C(C)C=C2)(C(F)(F)F)O)(C)(C)C3=C4C(=CC(F)=C3)CCO4 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (64.87 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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